Phospholipid Supply for Autophagosome Biogenesis

Damilola Isola, Zvulun Elazar

Research output: Contribution to journalReview articlepeer-review

Abstract

Autophagy is a cellular degradation pathway where double-membrane autophagosomes form de novo to engulf cytoplasmic material destined for lysosomal degradation. This process requires regulated membrane remodeling, beginning with the initial autophagosomal precursor and progressing to its elongation and maturation into a fully enclosed, fusion-capable vesicle. While the core protein machinery involved in autophagosome formation has been extensively studied over the past two decades, the role of phospholipids in this process has only recently been studied. This review focuses on the phospholipid composition of the phagophore membrane and the mechanisms that supply lipids to expand this unique organelle.

Original languageEnglish
Article number168691
JournalJournal of Molecular Biology
DOIs
StatePublished Online - 27 Jun 2024

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Molecular Biology

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