Pharmacological effects of vitamin D and its analogs: Recent developments

Amnon C. Sintov; Ludmilla Yarmolinsky; Arik Dahan; Shimon Ben-Shabat

doi:https://doi.org/10.1016/j.drudis.2014.06.008

Pharmacological effects of vitamin D and its analogs: Recent developments

Amnon C. Sintov, Ludmilla Yarmolinsky, Arik Dahan, Shimon Ben-Shabat

Ben-Gurion University of the Negev

Research output: Contribution to journal › Review article › peer-review

Abstract

Calcitriol, the hormonally active form of vitamin D, is well known for its diverse pharmacological activities, including modulation of cell growth, neuromuscular and immune function and reduction of inflammation. Calcitriol and its analogs exert potent effects on cellular differentiation and proliferation, regulate apoptosis and produce immunomodulatory effects. The purpose of this review is to provide information on various physiological and pharmacological activities of calcitriol and its newly discovered analogs. Special emphasis is given to skin diseases, cancer, diabetes and multiple sclerosis. A discussion is raised on the mechanisms of action of calcitriol and its analogs in various diseases, as well as on possible methods of delivery and targeting.

Original language	American English
Pages (from-to)	1769-1774
Number of pages	6
Journal	Drug Discovery Today
Volume	19
Issue number	11
DOIs	https://doi.org/10.1016/j.drudis.2014.06.008
State	Published - 1 Jan 2014

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1016/j.drudis.2014.06.008

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title = "Pharmacological effects of vitamin D and its analogs: Recent developments",

abstract = "Calcitriol, the hormonally active form of vitamin D, is well known for its diverse pharmacological activities, including modulation of cell growth, neuromuscular and immune function and reduction of inflammation. Calcitriol and its analogs exert potent effects on cellular differentiation and proliferation, regulate apoptosis and produce immunomodulatory effects. The purpose of this review is to provide information on various physiological and pharmacological activities of calcitriol and its newly discovered analogs. Special emphasis is given to skin diseases, cancer, diabetes and multiple sclerosis. A discussion is raised on the mechanisms of action of calcitriol and its analogs in various diseases, as well as on possible methods of delivery and targeting.",

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T1 - Pharmacological effects of vitamin D and its analogs

T2 - Recent developments

AU - Sintov, Amnon C.

AU - Yarmolinsky, Ludmilla

AU - Dahan, Arik

AU - Ben-Shabat, Shimon

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Calcitriol, the hormonally active form of vitamin D, is well known for its diverse pharmacological activities, including modulation of cell growth, neuromuscular and immune function and reduction of inflammation. Calcitriol and its analogs exert potent effects on cellular differentiation and proliferation, regulate apoptosis and produce immunomodulatory effects. The purpose of this review is to provide information on various physiological and pharmacological activities of calcitriol and its newly discovered analogs. Special emphasis is given to skin diseases, cancer, diabetes and multiple sclerosis. A discussion is raised on the mechanisms of action of calcitriol and its analogs in various diseases, as well as on possible methods of delivery and targeting.

AB - Calcitriol, the hormonally active form of vitamin D, is well known for its diverse pharmacological activities, including modulation of cell growth, neuromuscular and immune function and reduction of inflammation. Calcitriol and its analogs exert potent effects on cellular differentiation and proliferation, regulate apoptosis and produce immunomodulatory effects. The purpose of this review is to provide information on various physiological and pharmacological activities of calcitriol and its newly discovered analogs. Special emphasis is given to skin diseases, cancer, diabetes and multiple sclerosis. A discussion is raised on the mechanisms of action of calcitriol and its analogs in various diseases, as well as on possible methods of delivery and targeting.

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SN - 1359-6446

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SP - 1769

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JO - Drug Discovery Today

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IS - 11

ER -

Pharmacological effects of vitamin D and its analogs: Recent developments

Abstract

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