Pharmaco-miR: Linking microRNAs and drug effects

Jakob Lewin Rukov, Roni Wilentzik, Ishai Jaffe, Jeppe Vinther, Noam Shomron

Research output: Contribution to journalArticlepeer-review


MicroRNAs (miRNAs) are short regulatory RNAs that down-regulate gene expression. They are essential for cell homeostasis and active in many disease states. A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the field of 'miRNA pharmacogenomics'through 'Pharmaco-miRs'. miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. These interactions can be described as triplet sets consisting of a miRNA, a target gene and a drug associated with the gene. We have developed a web server which links miRNA expression and drug function by combining data on miRNA targeting and protein-drug interactions. miRNA targeting information derive from both experimental data and computational predictions, and protein-drug interactions are annotated by the Pharmacogenomics Knowledge base (PharmGKB). Pharmaco-miR's input consists of miRNAs, genes and/or drug names and the output consists of miRNA pharmacogenomic sets or a list of unique associated miRNAs, genes and drugs. We have furthermore built a database, named Pharmaco-miR Verified Sets (VerSe), which contains miRNA pharmacogenomic data manually curated from the literature, can be searched and downloaded via Pharmaco-miR and informs on trends and generalities published in the field. Overall, we present examples of how Pharmaco-miR provides possible explanations for previously published observations, including how the cisplatin and 5-fluorouracil resistance induced by miR-I48a may be caused by miR-I48a targeting of the gene KIT The information is available at

Original languageEnglish
Article numberbbs082
Pages (from-to)648-659
Number of pages12
JournalBriefings in Bioinformatics
Issue number4
StatePublished - Jul 2014


  • Database
  • MiRNA pharmacogenomic set
  • MicroRNAs
  • Pharmaco-miR
  • Pharmacogenomics
  • Web server

All Science Journal Classification (ASJC) codes

  • Information Systems
  • Molecular Biology


Dive into the research topics of 'Pharmaco-miR: Linking microRNAs and drug effects'. Together they form a unique fingerprint.

Cite this