PH-dependent switchable permeability from core-shell microcapsules

Joshua M. Grolman; Bora Inci; Jeffrey S. Moore

doi:https://doi.org/10.1021/acsmacrolett.5b00194

PH-dependent switchable permeability from core-shell microcapsules

Joshua M. Grolman, Bora Inci, Jeffrey S. Moore

Research output: Contribution to journal › Article › peer-review

Abstract

We recently reported cationic cyclopolymerization of o-vinylbenzaldehydes initiated by boron trifluoride to generate acid-sensitive poly(o-(α-alkyl)vinylbenzaldehyde). Herein we report preparation of core-shell microcapsules (μCs) using flow-focusing microfluidic techniques with shells composed of poly(o-(α-methyl)vinylbenzaldehyde) (PMVB) that release their payload in response to dilute aqueous acid solution. Release profiles of encapsulated fluorescein isothiocyanate-labeled dextran from μCs are controlled by varying the proton concentration and shell-wall thickness. SEM studies indicate that the system's unique reversible release mechanism involves porosity changes in the shell wall due to microcrack formation.

Original language	English
Pages (from-to)	441-445
Number of pages	5
Journal	ACS Macro Letters
Volume	4
Issue number	4
DOIs	https://doi.org/10.1021/acsmacrolett.5b00194
State	Published - 21 Apr 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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Cite this

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title = "PH-dependent switchable permeability from core-shell microcapsules",

abstract = "We recently reported cationic cyclopolymerization of o-vinylbenzaldehydes initiated by boron trifluoride to generate acid-sensitive poly(o-(α-alkyl)vinylbenzaldehyde). Herein we report preparation of core-shell microcapsules (μCs) using flow-focusing microfluidic techniques with shells composed of poly(o-(α-methyl)vinylbenzaldehyde) (PMVB) that release their payload in response to dilute aqueous acid solution. Release profiles of encapsulated fluorescein isothiocyanate-labeled dextran from μCs are controlled by varying the proton concentration and shell-wall thickness. SEM studies indicate that the system's unique reversible release mechanism involves porosity changes in the shell wall due to microcrack formation.",

author = "Grolman, {Joshua M.} and Bora Inci and Moore, {Jeffrey S.}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

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doi = "https://doi.org/10.1021/acsmacrolett.5b00194",

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T1 - PH-dependent switchable permeability from core-shell microcapsules

AU - Grolman, Joshua M.

AU - Inci, Bora

AU - Moore, Jeffrey S.

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Y1 - 2015/4/21

N2 - We recently reported cationic cyclopolymerization of o-vinylbenzaldehydes initiated by boron trifluoride to generate acid-sensitive poly(o-(α-alkyl)vinylbenzaldehyde). Herein we report preparation of core-shell microcapsules (μCs) using flow-focusing microfluidic techniques with shells composed of poly(o-(α-methyl)vinylbenzaldehyde) (PMVB) that release their payload in response to dilute aqueous acid solution. Release profiles of encapsulated fluorescein isothiocyanate-labeled dextran from μCs are controlled by varying the proton concentration and shell-wall thickness. SEM studies indicate that the system's unique reversible release mechanism involves porosity changes in the shell wall due to microcrack formation.

AB - We recently reported cationic cyclopolymerization of o-vinylbenzaldehydes initiated by boron trifluoride to generate acid-sensitive poly(o-(α-alkyl)vinylbenzaldehyde). Herein we report preparation of core-shell microcapsules (μCs) using flow-focusing microfluidic techniques with shells composed of poly(o-(α-methyl)vinylbenzaldehyde) (PMVB) that release their payload in response to dilute aqueous acid solution. Release profiles of encapsulated fluorescein isothiocyanate-labeled dextran from μCs are controlled by varying the proton concentration and shell-wall thickness. SEM studies indicate that the system's unique reversible release mechanism involves porosity changes in the shell wall due to microcrack formation.

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DO - https://doi.org/10.1021/acsmacrolett.5b00194

M3 - مقالة

SN - 2161-1653

VL - 4

SP - 441

EP - 445

JO - ACS Macro Letters

JF - ACS Macro Letters

IS - 4

ER -

PH-dependent switchable permeability from core-shell microcapsules

Abstract

All Science Journal Classification (ASJC) codes

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