TY - JOUR
T1 - Perinatal risk factors for bronchopulmonary dysplasia in a national cohort of very-low-birthweight infants
AU - Klinger, Gil
AU - Sokolover, Nir
AU - Boyko, Valentina
AU - Sirota, Lea
AU - Lerner-Geva, Liat
AU - Reichman, Brian
N1 - Funding Information: The Israel National Very Low Birth Weight Infant Database is partially funded by the Israel Center for Disease Control and the Ministry of Health.
PY - 2013/2
Y1 - 2013/2
N2 - Objective: We sought to assess the independent effect of perinatal factors on the risk for bronchopulmonary dysplasia (BPD) in very-low-birthweight infants. Study Design: This was a population-based observational study. Data were prospectively collected by the Israel Neonatal Network. Multivariable analyses identified independent risk factors for BPD. Results: Of 12,139 infants surviving to a postmenstrual age of 36 weeks, 1663 (13.7%) developed BPD. BPD was independently associated with young maternal age (odds ratio [OR], 1.53), maternal hypertensive disorders (OR, 1.28), antepartum hemorrhage (OR, 1.26), male gender (OR, 1.41), non-Jewish ethnicity (OR, 1.23), birth defects (OR, 1.94), small for gestational age (GA) (OR, 2.65), and delivery room resuscitation (OR, 1.86). Stratified analysis by GA groups showed that postdelivery resuscitation had a more pronounced effect with increasing maturity. Conclusion: Perinatal factors and pregnancy complications were independently associated with development of BPD in very-low-birthweight infants. Most risk factors identified were consistent within GA groups.
AB - Objective: We sought to assess the independent effect of perinatal factors on the risk for bronchopulmonary dysplasia (BPD) in very-low-birthweight infants. Study Design: This was a population-based observational study. Data were prospectively collected by the Israel Neonatal Network. Multivariable analyses identified independent risk factors for BPD. Results: Of 12,139 infants surviving to a postmenstrual age of 36 weeks, 1663 (13.7%) developed BPD. BPD was independently associated with young maternal age (odds ratio [OR], 1.53), maternal hypertensive disorders (OR, 1.28), antepartum hemorrhage (OR, 1.26), male gender (OR, 1.41), non-Jewish ethnicity (OR, 1.23), birth defects (OR, 1.94), small for gestational age (GA) (OR, 2.65), and delivery room resuscitation (OR, 1.86). Stratified analysis by GA groups showed that postdelivery resuscitation had a more pronounced effect with increasing maturity. Conclusion: Perinatal factors and pregnancy complications were independently associated with development of BPD in very-low-birthweight infants. Most risk factors identified were consistent within GA groups.
KW - bronchopulmonary dysplasia
KW - preterm infant
KW - risk factors
KW - very-low-birthweight
UR - http://www.scopus.com/inward/record.url?scp=84872864964&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2012.11.026
DO - 10.1016/j.ajog.2012.11.026
M3 - مقالة
SN - 0002-9378
VL - 208
SP - 115.e1-115.e9
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 2
ER -