Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity

Yael Zlotnikov-Klionsky; Bar Nathansohn-Levi; Elias Shezen; Chava Rosen; Sivan Kagan; Liat Bar-On; Steffen Jung; Eric Shifrut; Shlomit Reich-Zeliger; Nir Friedman; Rina Aharoni; Ruth Arnon; Oren Yifa; Anna Aronovich; Yair Reisner

doi:https://doi.org/10.1016/j.immuni.2015.08.015

Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity

Yael Zlotnikov-Klionsky, Bar Nathansohn-Levi, Elias Shezen, Chava Rosen, Sivan Kagan, Liat Bar-On, Steffen Jung, Eric Shifrut, Shlomit Reich-Zeliger, Nir Friedman, Rina Aharoni, Ruth Arnon, Oren Yifa, Anna Aronovich, Yair Reisner

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Emerging evidence suggests that immunological mechanisms underlie metabolic control of adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs). Using bone marrow transplantation to generate animals selectively lacking perf-DCs, we found that these chimeras progressively gained weight and exhibited features of metabolic syndrome. This phenotype was associated with an altered repertoire of T cells residing in adipose tissue and could be completely prevented by T cell depletion in vivo. A similar impact of perf-DCs on inflammatory T cells was also found in a well-defined model of multiple sclerosis, experimental autoimmune encephlalomyelitis (EAE). Thus, perf-DCs probably represent a regulatory cell subpopulation critical for protection from metabolic syndrome and autoimmunity.

Original language	English
Article number	3173
Pages (from-to)	776-787
Number of pages	12
Journal	Immunity
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2015.08.015
State	Published - 20 Oct 2015

All Science Journal Classification (ASJC) codes

Infectious Diseases
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Zlotnikov-Klionsky, Y., Nathansohn-Levi, B., Shezen, E., Rosen, C., Kagan, S., Bar-On, L., Jung, S., Shifrut, E., Reich-Zeliger, S., Friedman, N., Aharoni, R., Arnon, R., Yifa, O., Aronovich, A., & Reisner, Y. (2015). Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity. Immunity, 43(4), 776-787. Article 3173. https://doi.org/10.1016/j.immuni.2015.08.015

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abstract = "Emerging evidence suggests that immunological mechanisms underlie metabolic control of adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs). Using bone marrow transplantation to generate animals selectively lacking perf-DCs, we found that these chimeras progressively gained weight and exhibited features of metabolic syndrome. This phenotype was associated with an altered repertoire of T cells residing in adipose tissue and could be completely prevented by T cell depletion in vivo. A similar impact of perf-DCs on inflammatory T cells was also found in a well-defined model of multiple sclerosis, experimental autoimmune encephlalomyelitis (EAE). Thus, perf-DCs probably represent a regulatory cell subpopulation critical for protection from metabolic syndrome and autoimmunity.",

author = "Yael Zlotnikov-Klionsky and Bar Nathansohn-Levi and Elias Shezen and Chava Rosen and Sivan Kagan and Liat Bar-On and Steffen Jung and Eric Shifrut and Shlomit Reich-Zeliger and Nir Friedman and Rina Aharoni and Ruth Arnon and Oren Yifa and Anna Aronovich and Yair Reisner",

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Zlotnikov-Klionsky, Y, Nathansohn-Levi, B, Shezen, E, Rosen, C, Kagan, S, Bar-On, L, Jung, S , Shifrut, E, Reich-Zeliger, S, Friedman, N, Aharoni, R, Arnon, R, Yifa, O, Aronovich, A & Reisner, Y 2015, 'Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity', Immunity, vol. 43, no. 4, 3173, pp. 776-787. https://doi.org/10.1016/j.immuni.2015.08.015

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T1 - Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity

AU - Zlotnikov-Klionsky, Yael

AU - Nathansohn-Levi, Bar

AU - Shezen, Elias

AU - Rosen, Chava

AU - Kagan, Sivan

AU - Bar-On, Liat

AU - Jung, Steffen

AU - Shifrut, Eric

AU - Reich-Zeliger, Shlomit

AU - Friedman, Nir

AU - Aharoni, Rina

AU - Arnon, Ruth

AU - Yifa, Oren

AU - Aronovich, Anna

AU - Reisner, Yair

PY - 2015/10/20

Y1 - 2015/10/20

N2 - Emerging evidence suggests that immunological mechanisms underlie metabolic control of adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs). Using bone marrow transplantation to generate animals selectively lacking perf-DCs, we found that these chimeras progressively gained weight and exhibited features of metabolic syndrome. This phenotype was associated with an altered repertoire of T cells residing in adipose tissue and could be completely prevented by T cell depletion in vivo. A similar impact of perf-DCs on inflammatory T cells was also found in a well-defined model of multiple sclerosis, experimental autoimmune encephlalomyelitis (EAE). Thus, perf-DCs probably represent a regulatory cell subpopulation critical for protection from metabolic syndrome and autoimmunity.

AB - Emerging evidence suggests that immunological mechanisms underlie metabolic control of adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs). Using bone marrow transplantation to generate animals selectively lacking perf-DCs, we found that these chimeras progressively gained weight and exhibited features of metabolic syndrome. This phenotype was associated with an altered repertoire of T cells residing in adipose tissue and could be completely prevented by T cell depletion in vivo. A similar impact of perf-DCs on inflammatory T cells was also found in a well-defined model of multiple sclerosis, experimental autoimmune encephlalomyelitis (EAE). Thus, perf-DCs probably represent a regulatory cell subpopulation critical for protection from metabolic syndrome and autoimmunity.

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M3 - مقالة

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SN - 1074-7613

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JO - Immunity

JF - Immunity

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ER -

Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity

Abstract

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