Peptide hydrogen-bonded organic frameworks

Thangavel Vijayakanth, Sneha Dasgupta, Pragati Ganatra, Sigal Rencus-Lazar, Aamod V. Desai, Shyamapada Nandi, Rahul Jain, Santu Bera, Andy I. Nguyen, Ehud Gazit, Rajkumar Misra

Research output: Contribution to journalReview articlepeer-review


Hydrogen-bonded porous frameworks (HPFs) are versatile porous crystalline frameworks with diverse applications. However, designing chiral assemblies or biocompatible materials poses significant challenges. Peptide-based hydrogen-bonded porous frameworks (P-HPFs) are an exciting alternative to conventional HPFs due to their intrinsic chirality, tunability, biocompatibility, and structural diversity. Flexible, ultra-short peptide-based P-HPFs (composed of 3 or fewer amino acids) exhibit adaptable porous topologies that can accommodate a variety of guest molecules and capture hazardous greenhouse gases. Longer, folded peptides present challenges and opportunities in designing P-HPFs. This review highlights recent developments in P-HPFs using ultra-short peptides, folded peptides, and foldamers, showcasing their utility for gas storage, chiral recognition, chiral separation, and medical applications. It also addresses design challenges and future directions in the field.

Original languageEnglish
Pages (from-to)3640-3655
Number of pages16
JournalChemical Society Reviews
Issue number8
StatePublished - 7 Mar 2024

All Science Journal Classification (ASJC) codes

  • General Chemistry


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