Peptide Bond Formation in the Protonated Serine Dimer Following Vacuum UV Photon-Induced Excitation

Ori Licht, Darío Barreiro-Lage, Patrick Rousseau, Alexandre Giuliani, Aleksandar R. Milosavljević, Avinoam Isaak, Yitzhak Mastai, Amnon Albeck, Raj Singh, Vy T.T. Nguyen, Laurent Nahon, Lara Martínez-Fernández, Sergio Díaz-Tendero, Yoni Toker

Research output: Contribution to journalArticlepeer-review


Possible routes for intra-cluster bond formation (ICBF) in protonated serine dimers have been studied. We found no evidence of ICBF following low energy collision-induced dissociation (in correspondence with previous works), however, we do observe clear evidence for ICBF following photon absorption in the 4.6–14 eV range. Moreover, the comparison of photon-induced dissociation measurements of the protonated serine dimer to those of a protonated serine dipeptide provides evidence that ICBF, in this case, involves peptide bond formation (PBF). The experimental results are supported by ab initio molecular dynamics and exploration of several excited state potential energy surfaces, unraveling a pathway for PBF following photon absorption. The combination of experiments and theory provides insight into the PBF mechanisms in clusters of amino acids, and reveals the importance of electronic excited states reached upon UV/VUV light excitation.

Original languageEnglish
Article numbere202218770
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number15
StatePublished - 3 Apr 2023


  • Cluster Compounds
  • Gas-Phase Reactions
  • Mass Spectrometry
  • Quantum Chemistry
  • UV/Vis Spectroscopy

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Catalysis


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