PathWeigh – Quantifying the Behavior of Biochemical Pathway Cascades

Dani Livne, Sol Efroni

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Biochemical pathways analysis is an effective tool for understanding changes in gene expression data and associating such changes with cellular phenotypes. Pathway research aims to identify associated proteins within a cell using pathways and at building new pathways from a group of molecules of interest. Using pathway-based methods we gain insight into different functions of relevant molecules and find direct and indirect relations between them. We present PathWeigh, a Python-based tool for pathway analysis and graph presentation. The tool is open-sourced, extendable and runtime efficient. PathWeigh is available at https://github.org/zurkin1/Pathweigh and is released under MIT license. A sample Python notebook is provided with examples of running the tool.

Original languageEnglish
Title of host publicationBioinformatics and Biomedical Engineering - 9th International Work-Conference, IWBBIO 2022, Proceedings
EditorsIgnacio Rojas, Olga Valenzuela, Fernando Rojas, Luis Javier Herrera, Francisco Ortuño
PublisherSpringer Science and Business Media Deutschland GmbH
Pages346-352
Number of pages7
ISBN (Print)9783031078019
DOIs
StatePublished - 2022
Event9th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2022 - Gran Canaria, Spain
Duration: 27 Jun 202230 Jun 2022

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume13347 LNBI

Conference

Conference9th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2022
Country/TerritorySpain
CityGran Canaria
Period27/06/2230/06/22

Keywords

  • Machine learning
  • Pathway analysis
  • RNA sequencing

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • General Computer Science

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