Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance

Zixiao Yin, Ruoyu Ma, Qi An, Yichen Xu, Yifei Gan, Guanyu Zhu, Yin Jiang, Ning Zhang, Anchao Yang, Fangang Meng, Andrea A. Kühn, Hagai Bergman, Wolf Julian Neumann, Jianguo Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is unknown. To investigate the clinical potential of beta activity as a biomarker for sleep quality in PD, we recorded pallidal local field potentials during polysomnography in PD patients off dopaminergic medication and compared the results to dystonia patients. PD patients exhibited sustained and elevated beta activity across wakefulness, rapid eye movement (REM), and non-REM sleep, which was correlated with sleep disturbance. Simulation of adaptive stimulation revealed that sleep-related beta activity changes remain unaccounted for by current algorithms, with potential negative outcomes in sleep quality and overall quality of life for patients.

Original languageAmerican English
Article number5434
JournalNature Communications
Volume14
Issue number1
DOIs
StatePublished - Dec 2023

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General Physics and Astronomy

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