TY - JOUR
T1 - Pathogen-derived extracellular vesicles coordinate social behaviour and host manipulation
AU - Ofir Birin, Birin, Yifat
AU - Heidenreich, Meta
AU - Regev-Rudzki, Neta
N1 - We thank Dr. Dejan Bursac and Maya Olshina for critical scientific reading of the manuscript.
PY - 2017/7
Y1 - 2017/7
N2 - Infectious diseases are the leading cause of death of children worldwide, causing a tenacious and major public-health burden. The dynamic interplay between pathogens and their host is one of the most complicated themes of the disease progression. Pathogens excel in developing different means to facilitate cell-cell communication via secreted vesicles, among others. The released vesicles are involved in the transfer of biologically active molecules that induce phenotypic changes in the recipient cells. The messages within the vesicles are delivered to coordinate diverse processes, including virulence factor expression, differentiation state and control of their population density. Importantly, production of such vesicles promotes pathogen survival, as it provides a secure means of pathogen-pathogen communication and an ability to manipulate host responses for their own benefits. This review highlights intriguing findings, which show the important role of EVs in the social activity of pathogens, within and in between their communities. We further present examples of how pathogens use EVs to alter host immune and non-immune responses. Advancing our understanding of cell-cell communication in infectious diseases will be particularly useful to decipher the complexity of the crosstalk between pathogens themselves and their hosts, leading to the development of therapeutic strategies for fighting infectious agents. (C) 2017 Elsevier Ltd. All rights reserved.
AB - Infectious diseases are the leading cause of death of children worldwide, causing a tenacious and major public-health burden. The dynamic interplay between pathogens and their host is one of the most complicated themes of the disease progression. Pathogens excel in developing different means to facilitate cell-cell communication via secreted vesicles, among others. The released vesicles are involved in the transfer of biologically active molecules that induce phenotypic changes in the recipient cells. The messages within the vesicles are delivered to coordinate diverse processes, including virulence factor expression, differentiation state and control of their population density. Importantly, production of such vesicles promotes pathogen survival, as it provides a secure means of pathogen-pathogen communication and an ability to manipulate host responses for their own benefits. This review highlights intriguing findings, which show the important role of EVs in the social activity of pathogens, within and in between their communities. We further present examples of how pathogens use EVs to alter host immune and non-immune responses. Advancing our understanding of cell-cell communication in infectious diseases will be particularly useful to decipher the complexity of the crosstalk between pathogens themselves and their hosts, leading to the development of therapeutic strategies for fighting infectious agents. (C) 2017 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.semcdb.2017.03.004
DO - 10.1016/j.semcdb.2017.03.004
M3 - مقالة مرجعية
SN - 1084-9521
VL - 67
SP - 83
EP - 90
JO - SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
JF - SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
ER -