TY - JOUR
T1 - Particulate Matter Toxicity Is Nrf2 and Mitochondria Dependent
T2 - The Roles of Metals and Polycyclic Aromatic Hydrocarbons
AU - Pardo, Michal
AU - Qiu, Xinghua
AU - Zimmermann, Ralf
AU - Rudich, Yinon
N1 - This research was partially supported by research grants from the Israeli Ministry of Science (grant # 3-14010) and the Weizmann Institute of Science in the framework of the AeroHEALTH Helmholtz International Lab, a German-Israeli project.
PY - 2020/5/18
Y1 - 2020/5/18
N2 - Particulate matter (PM), an important component of air pollution, induces significant adverse health effects. Many of the observed health effects caused by inhaled PM are associated with oxidative stress and inflammation. This association has been linked in particular to the particles’ chemical components, especially the inorganic/metal and the organic/polycyclic aromatic hydrocarbon (PAH) fractions, and their ability to generate reactive oxygen species (ROS) in biological systems. The transcription factor NF-E2 nuclear factor erythroid-related factor 2 (Nrf2) is activated by redox imbalance and regulates the expression of phase II detoxifying enzymes. Nrf2 plays a key role in preventing PM-induced toxicity by protecting against oxidative damage and inflammation. This review focuses on specific PM fractions, particularly the dissolved metals and PAH fractions, and their roles in inducing oxidative stress and inflammation in cell and animal models with respect to Nrf2 and mitochondria.
AB - Particulate matter (PM), an important component of air pollution, induces significant adverse health effects. Many of the observed health effects caused by inhaled PM are associated with oxidative stress and inflammation. This association has been linked in particular to the particles’ chemical components, especially the inorganic/metal and the organic/polycyclic aromatic hydrocarbon (PAH) fractions, and their ability to generate reactive oxygen species (ROS) in biological systems. The transcription factor NF-E2 nuclear factor erythroid-related factor 2 (Nrf2) is activated by redox imbalance and regulates the expression of phase II detoxifying enzymes. Nrf2 plays a key role in preventing PM-induced toxicity by protecting against oxidative damage and inflammation. This review focuses on specific PM fractions, particularly the dissolved metals and PAH fractions, and their roles in inducing oxidative stress and inflammation in cell and animal models with respect to Nrf2 and mitochondria.
UR - http://www.scopus.com/inward/record.url?scp=85084937225&partnerID=8YFLogxK
U2 - 10.1021/acs.chemrestox.0c00007
DO - 10.1021/acs.chemrestox.0c00007
M3 - مقالة مرجعية
C2 - 32302097
SN - 0893-228X
VL - 33
SP - 1110
EP - 1120
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
IS - 5
ER -