Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Muhammad AbdEl-haq; Awanish Kumar; Fatima Ezzahra Ait Mohand; Nataly Kravchenko-Balasha; Yakir Rottenberg; Abraham J. Domb

doi:https://doi.org/10.3390/ijms241411722

Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Muhammad AbdEl-haq, Awanish Kumar, Fatima Ezzahra Ait Mohand, Nataly Kravchenko-Balasha, Yakir Rottenberg, Abraham J. Domb

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.

Original language	English
Article number	11722
Journal	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume	24
Issue number	14
DOIs	https://doi.org/10.3390/ijms241411722
State	Published - 21 Jul 2023

Keywords

brain delivery
glioblastoma treatment
intranasal (IN)
intravenous (IV)
nanoparticles (NPs)
paclitaxel (PTX)
poly(lactic-co-glycolic acid) (PLGA)

All Science Journal Classification (ASJC) codes

Molecular Biology
Spectroscopy
Catalysis
Inorganic Chemistry
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.3390/ijms241411722

Cite this

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title = "Paclitaxel Delivery to the Brain for Glioblastoma Treatment",

abstract = "The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.",

keywords = "brain delivery, glioblastoma treatment, intranasal (IN), intravenous (IV), nanoparticles (NPs), paclitaxel (PTX), poly(lactic-co-glycolic acid) (PLGA)",

author = "Muhammad AbdEl-haq and Awanish Kumar and {Ait Mohand}, {Fatima Ezzahra} and Nataly Kravchenko-Balasha and Yakir Rottenberg and Domb, {Abraham J.}",

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doi = "https://doi.org/10.3390/ijms241411722",

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T1 - Paclitaxel Delivery to the Brain for Glioblastoma Treatment

AU - AbdEl-haq, Muhammad

AU - Kumar, Awanish

AU - Ait Mohand, Fatima Ezzahra

AU - Kravchenko-Balasha, Nataly

AU - Rottenberg, Yakir

AU - Domb, Abraham J.

PY - 2023/7/21

Y1 - 2023/7/21

N2 - The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.

AB - The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.

KW - brain delivery

KW - glioblastoma treatment

KW - intranasal (IN)

KW - intravenous (IV)

KW - nanoparticles (NPs)

KW - paclitaxel (PTX)

KW - poly(lactic-co-glycolic acid) (PLGA)

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M3 - مقالة

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SN - 1661-6596

VL - 24

JO - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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M1 - 11722

ER -

Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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