Abstract
Abstract Text: Introduction: Non-dipping of blood pressure (BP) levels is frequent in type 2 diabetes (T2D) and is independently associated with increased cardiovascular risk. However, less is known
about its differential association with weight in T2D.Methods: As part
of clinical trial, we measured office (second measurement) and 24h
Ambulatory Blood Pressure Monitoring (ABPM) in 54 patients with
T2D (85% men;35% taking anti-hypertensive drugs) and compared
dynamics of BP between across weight groups (median cut-point=
81.6kg).Results: The mean age was 57yrs±6.4;BMI 29.2 kg/m±2.4,
and HbA1c 7.6%±1.4. Anti-hypertensive drugs usage was similar in
both groups. Mean office BP were 128.4±11.5/79±8.8mmHg and mean
ABPM were 129.2±12.8/76.6±8.3mmHg (peak levels of systolic BP was
at 8AM 136.1mmHg, and 83.2mmHg for the diastolic at 12AM; nadir levels
were at 2AM of 115.3/64.9mmHg systolic). The dynamic of BP was not altered by levels of HbA1c. However, higher significant levels among the relatively overweight patients (Figure 1) were observed in the systolic ABPM
(133mmHg vs. 125.3mmHg; pv=0.017) but not in the office BP. The
higher significant systolic levels among the overweight patients was found
only after midnight, and particularly at dawn time: at 2AM (120.9mmHg
vs. 110.3mmHg;pv=0.044), 5AM (128.9mmHg vs. 114mmHg;pv=0.005)
and 6AM (136mmHg vs. 123.2mmHg;pv=0.039). Conclusions: 24h
monitoring indicates that overweight patients have a lesser nocturnal dip
and an earlier morning BP surge compared to less-overweight patients
with T2D.
about its differential association with weight in T2D.Methods: As part
of clinical trial, we measured office (second measurement) and 24h
Ambulatory Blood Pressure Monitoring (ABPM) in 54 patients with
T2D (85% men;35% taking anti-hypertensive drugs) and compared
dynamics of BP between across weight groups (median cut-point=
81.6kg).Results: The mean age was 57yrs±6.4;BMI 29.2 kg/m±2.4,
and HbA1c 7.6%±1.4. Anti-hypertensive drugs usage was similar in
both groups. Mean office BP were 128.4±11.5/79±8.8mmHg and mean
ABPM were 129.2±12.8/76.6±8.3mmHg (peak levels of systolic BP was
at 8AM 136.1mmHg, and 83.2mmHg for the diastolic at 12AM; nadir levels
were at 2AM of 115.3/64.9mmHg systolic). The dynamic of BP was not altered by levels of HbA1c. However, higher significant levels among the relatively overweight patients (Figure 1) were observed in the systolic ABPM
(133mmHg vs. 125.3mmHg; pv=0.017) but not in the office BP. The
higher significant systolic levels among the overweight patients was found
only after midnight, and particularly at dawn time: at 2AM (120.9mmHg
vs. 110.3mmHg;pv=0.044), 5AM (128.9mmHg vs. 114mmHg;pv=0.005)
and 6AM (136mmHg vs. 123.2mmHg;pv=0.039). Conclusions: 24h
monitoring indicates that overweight patients have a lesser nocturnal dip
and an earlier morning BP surge compared to less-overweight patients
with T2D.
| Original language | American English |
|---|---|
| Pages (from-to) | 103-104 |
| Number of pages | 2 |
| Journal | Obesity Facts |
| Volume | 5 |
| DOIs | |
| State | Published - May 2012 |
