@article{0d88c0fb1ff7408da7ffe74f61458ea5,
title = "Our Gut Microbiome: The Evolving Inner Self",
abstract = "The {"}holobiont'' concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolving microbial-host associations and relations during distinct milestones across the lifespan of a human being. We discuss the current knowledge of biological symbiosis between the microbiome and its host and portray the challenges in understanding these interactions and their potential effects on human physiology, including microbiome-nervous system inter-relationship and its relevance to human variation and individuality.",
author = "Parag Kundu and Eran Blacher and Eran Elinav and Sven Pettersson",
note = "We thank the members of the Elinav and Pettersson laboratories for discussions and apologize to authors whose work was not included in this review due to space constraints. E.E. is supported by Y. and R. Ungar , the Abisch Frenkel Foundation for the Promotion of Life Sciences , the Gurwin Family Fund for Scientific Research , the Leona M. and Harry B. Helmsley Charitable Trust , the Crown Endowment Fund for Immunological Research , the estate of J. Gitlitz, the estate of L. Hershkovich, the Benoziyo Endowment Fund for the Advancement of Science , the Adelis Foundation , J.L. and V. Schwartz, A. and G. Markovitz, A. and C. Adelson, the French National Center for Scientific Research (CNRS) , D.L. Schwarz; The V.R. Schwartz Research Fellow Chair , L. Steinberg, J.N. Halpern, and A. Edelheit, as well as by grants funded by the European Research Council , a Marie Curie Integration grant, the German-Israeli Foundation for Scientific Research and Development , the Israel Science Foundation , the Minerva Foundation , the Rising Tide Foundation , the Helmholtz Foundation , and the European Foundation for the Study of Diabetes . E.E. is an international scholar of Howard Hughes Medical Institute (HHMI). S.P. is supported by Lee Kong Chian School of Medicine ( SUG 2017-001 ); Singapore Centre on Environmental Life Sciences Engineering ; NTU Integrated, Medical and Biological and Envieronmental Life Sciences (NIMBELS) ( 50025000 ), and NTU Food Technology Center (NAFTEC) at Nanyang Technological University ; and TIER 1 grant Ministry Of Education ( 2016-T1-002-070 ). E.E. and S.P. are senior fellows of Canadian Institute of Advanced Research (CIFAR). E.E. and S.P. are grateful for the continuous support from CIFAR and valuable input from CIFAR colleagues.",
year = "2017",
month = dec,
day = "14",
doi = "https://doi.org/10.1016/j.cell.2017.11.024",
language = "الإنجليزيّة",
volume = "171",
pages = "1481--1493",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "7",
}