@inproceedings{9a42d0aba6fc44af942fa492c20b2822,
title = "Osmotic erythrocyte lysis for chemical- and label-free impedance cytometry",
abstract = "We present the first implementation of osmotic erythrocyte (RBC) lysis for microfluidic leukocyte (WBC) impedance cytometry. The method relies on osmotic pressure differentials to rupture RBC membranes, and detection of WBCs based on changes in impedance. Specifically, we demonstrate an up to 1,200-fold decrease in noise from RBCs in WBC recordings. Our approach enables lab-on-a-chip (LOC)-based WBC counting on whole blood samples without traditionally required chemicals or labels.",
keywords = "Microsystem integration, impedance cytometry, lab-on-a-chip, microfluidics, osmotic lysis",
author = "Winkler, {T. E.} and H. Ben-Yoav and Kelly, {D. L.} and R. Ghodssi",
note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 ; Conference date: 21-06-2015 Through 25-06-2015",
year = "2015",
month = aug,
day = "5",
doi = "10.1109/TRANSDUCERS.2015.7180933",
language = "American English",
series = "2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015",
pages = "351--354",
booktitle = "2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015",
}