Optimization of transport processes in etched track-based biosensors

Dietmar Fink; Jiri Vacik; Lital Alfonta; Arik Kiv; Yohai Mandabi; G. Muñoz H.

doi:10.1080/10420150.2011.647914

Optimization of transport processes in etched track-based biosensors

Dietmar Fink, Jiri Vacik, Lital Alfonta, Arik Kiv, Yohai Mandabi, G. Muñoz H.

Department of Biotechnology Engineering

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

A diffusion calculation was performed to simulate the migration kinetics of both analytes and enzymatic reaction products in enzyme-clad nanopores of different sizes and shapes, to estimate the limits of detection, response time and cleaning time of such biosensors, via the maximum possible reaction product enrichment in such pores and the time required for saturation of the corresponding concentration distributions. From this, conclusions concerning the optimum biosensor dimensions are derived.

Original language	American English
Pages (from-to)	548-568
Number of pages	21
Journal	Radiation Effects and Defects in Solids
Volume	167
Issue number	8
DOIs	https://doi.org/10.1080/10420150.2011.647914
State	Published - 1 Aug 2012

Keywords

biotechnology
diffusion
polymers
theory

All Science Journal Classification (ASJC) codes

Radiation
Nuclear and High Energy Physics
General Materials Science
Condensed Matter Physics

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10.1080/10420150.2011.647914

Cite this

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title = "Optimization of transport processes in etched track-based biosensors",

abstract = "A diffusion calculation was performed to simulate the migration kinetics of both analytes and enzymatic reaction products in enzyme-clad nanopores of different sizes and shapes, to estimate the limits of detection, response time and cleaning time of such biosensors, via the maximum possible reaction product enrichment in such pores and the time required for saturation of the corresponding concentration distributions. From this, conclusions concerning the optimum biosensor dimensions are derived.",

keywords = "biotechnology, diffusion, polymers, theory",

author = "Dietmar Fink and Jiri Vacik and Lital Alfonta and Arik Kiv and Yohai Mandabi and \{Mu{\~n}oz H.\}, G.",

note = "Funding Information: This work was performed within the frame of the guest professorship on the Cathedra Marcos Menzer Mazari at the Universidad Aut{\'o}noma Metropolitana, Iztapalapa, M{\'e}xico City. We are especially obliged to Prof. Salvador Cruz for his everlasting interest in this topic and for numerous valuable discussions. Thanks also to Profs G. Mu{\~n}oz H., J.C. Ter{\'a}n and Mr N. Camarillo for their continuous help and for providing us with adequate working facilities. We also want to acknowledge the very careful and valuable reviewing of the referee which helped improving this work considerably. We also acknowledge the support from the Grant Agency of the Academy of Sciences of the Czech Republic (Research project no. IAA 200480702) for performing some of the examinations at the Nuclear Physics Institute in Rˇ e{\v z}, Czech Republic. Last but not least, we are obliged to Dr P. Apel from JNRI Dubna, Russia for providing us with the ion-irradiated polymer foils.",

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doi = "10.1080/10420150.2011.647914",

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AU - Fink, Dietmar

AU - Vacik, Jiri

AU - Alfonta, Lital

AU - Kiv, Arik

AU - Mandabi, Yohai

AU - Muñoz H., G.

N1 - Funding Information: This work was performed within the frame of the guest professorship on the Cathedra Marcos Menzer Mazari at the Universidad Autónoma Metropolitana, Iztapalapa, México City. We are especially obliged to Prof. Salvador Cruz for his everlasting interest in this topic and for numerous valuable discussions. Thanks also to Profs G. Muñoz H., J.C. Terán and Mr N. Camarillo for their continuous help and for providing us with adequate working facilities. We also want to acknowledge the very careful and valuable reviewing of the referee which helped improving this work considerably. We also acknowledge the support from the Grant Agency of the Academy of Sciences of the Czech Republic (Research project no. IAA 200480702) for performing some of the examinations at the Nuclear Physics Institute in Rˇ ež, Czech Republic. Last but not least, we are obliged to Dr P. Apel from JNRI Dubna, Russia for providing us with the ion-irradiated polymer foils.

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N2 - A diffusion calculation was performed to simulate the migration kinetics of both analytes and enzymatic reaction products in enzyme-clad nanopores of different sizes and shapes, to estimate the limits of detection, response time and cleaning time of such biosensors, via the maximum possible reaction product enrichment in such pores and the time required for saturation of the corresponding concentration distributions. From this, conclusions concerning the optimum biosensor dimensions are derived.

AB - A diffusion calculation was performed to simulate the migration kinetics of both analytes and enzymatic reaction products in enzyme-clad nanopores of different sizes and shapes, to estimate the limits of detection, response time and cleaning time of such biosensors, via the maximum possible reaction product enrichment in such pores and the time required for saturation of the corresponding concentration distributions. From this, conclusions concerning the optimum biosensor dimensions are derived.

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KW - diffusion

KW - polymers

KW - theory

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ER -

Optimization of transport processes in etched track-based biosensors

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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