Optimization of transport processes in etched track-based biosensors

Dietmar Fink, Jiri Vacik, Lital Alfonta, Arik Kiv, Yohai Mandabi, G. Muñoz H.

Research output: Contribution to journalArticlepeer-review

Abstract

A diffusion calculation was performed to simulate the migration kinetics of both analytes and enzymatic reaction products in enzyme-clad nanopores of different sizes and shapes, to estimate the limits of detection, response time and cleaning time of such biosensors, via the maximum possible reaction product enrichment in such pores and the time required for saturation of the corresponding concentration distributions. From this, conclusions concerning the optimum biosensor dimensions are derived.

Original languageAmerican English
Pages (from-to)548-568
Number of pages21
JournalRadiation Effects and Defects in Solids
Volume167
Issue number8
DOIs
StatePublished - 1 Aug 2012

Keywords

  • biotechnology
  • diffusion
  • polymers
  • theory

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Nuclear and High Energy Physics
  • Radiation
  • General Materials Science

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