Optical sensors for monitoring enzymatic activity

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Semiconducting single-walled carbon nanotubes (SWCNTs) fluoresce in the near-infrared (NIR), which overlaps with the optical transparency window of biological samples. Their biocompatibility, lack of photobleaching, and ease of surface functionalization render them ideal for optical sensing. We highlight strategies to monitor enzymatic activity using SWCNTs, including incorporating enzyme-specific target bonds in the SWCNT corona or detecting the hydrolytic products of enzymatic activity. These approaches enable sensitive, real-time monitoring of enzymatic processes. Recent applications in clinically relevant samples showcase the potential of SWCNT-based sensors in advancing biomedical diagnostics and therapeutic monitoring.

Original languageEnglish
Title of host publicationFrontiers in Biological Detection
Subtitle of host publicationFrom Nanosensors to Systems XVII
EditorsAmos Danielli, Benjamin L. Miller, Sharon M. Weiss
PublisherSPIE
ISBN (Electronic)9781510684249
DOIs
StatePublished - 2025
EventFrontiers in Biological Detection: From Nanosensors to Systems XVII 2025 - San Francisco, United States
Duration: 25 Jan 202527 Jan 2025

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume13338

Conference

ConferenceFrontiers in Biological Detection: From Nanosensors to Systems XVII 2025
Country/TerritoryUnited States
CitySan Francisco
Period25/01/2527/01/25

Keywords

  • Single-walled carbon nanotubes
  • near-infrared fluorescence
  • optical nanosensors

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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