@article{5aa8131a18d543a1b9fcf4f5064ede35,
title = "Optical assessment of nociceptive TRP channel function at the peripheral nerve terminal",
abstract = "Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP channel function is limited to data obtained from in vitro models which do not necessarily reflect physiological conditions. In recent years, the development of novel optical methods such as genetically encoded calcium indicators and photo-modulation of ion channel activity by pharmacological tools has provided an invaluable opportunity to directly assess nociceptive TRP channel function at the nerve terminal.",
keywords = "Nociception, Optical recording, Opto-pharmacology, Pain, Peripheral nerve terminals, TRP channels, nociception, optical recording, opto-pharmacology, pain, peripheral nerve terminals",
author = "Fernando Aleixandre-Carrera and Nurit Engelmayer and David Ares-Su{\'a}rez and Acosta, {Mar{\'i}a del Carmen} and Carlos Belmonte and Juana Gallar and V{\'i}ctor Meseguer and Binshtok, {Alexander M.}",
note = "Funding Information: Funding: This work was funded by The Spanish Agencia Estatal de Investigaci{\'o}n and the European Regional Development Fund grants RTI2018-100994-AI00 and SAF2017-83674-C2-2-R and -1-R, The Spanish Ministerio de Universidades Fellowship FPU17/00483, The Generalitat Valenciana Excellence Project Program grant PROMETEO/2018/114, The Israeli Science Foundation, grant agreement 1470/17, Canadian Institutes of Health Research (CIHR), the International Development Research Centre (IDRC), the Israel Science Foundation (ISF) and the Azrieli Foundation, grant agreement 2545/18, and the Deutsch-Israelische Projectkooperation Program of the Deutsche Forschungsge-meinschaft (DIP), grant agreement BI 1665/1-1ZI1172/12-1. Funding Information: This work was funded by The Spanish Agencia Estatal de Investigaci?n and the European Regional Development Fund grants RTI2018-100994-AI00 and SAF2017-83674-C2-2-R and-1-R, The Spanish Ministerio de Universidades Fellowship FPU17/00483, The Generalitat Valenciana Excel-lence Project Program grant PROMETEO/2018/114, The Israeli Science Foundation, grant agreement 1470/17, Canadian Institutes of Health Research (CIHR), the International Development Research Centre (IDRC), the Israel Science Foundation (ISF) and the Azrieli Foundation, grant agreement 2545/18, and the Deutsch-Israelische Projectkooperation Program of the Deutsche Forschungsge-meinschaft (DIP), grant agreement BI 1665/1-1ZI1172/12-1. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jan,
day = "2",
doi = "https://doi.org/10.3390/ijms22020481",
language = "English",
volume = "22",
pages = "1--20",
journal = "INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES",
issn = "1661-6596",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "2",
}