Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency

Sharon Schlesinger; Eran Meshorer

doi:https://doi.org/10.1016/j.devcel.2019.01.003

Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency

Sharon Schlesinger, Eran Meshorer

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Pluripotent embryonic stem cells are considered to have open and accessible chromatin relative to differentiated cells. Schlesinger and Meshorer review chromatin and epigenetic features in 2i- versus serum-grown conditions to come to a clearer picture of the genuine characteristics of pluripotency as opposed to artifacts of culture condition.

Original language	English
Pages (from-to)	135-150
Number of pages	16
Journal	Developmental Cell
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2019.01.003
State	Published - 28 Jan 2019

Keywords

2i
chromatin
chromatin plasticity
differentiation
embryonic stem cells
epigenetics
ground state
naive
nuclear plasticity
pluripotency
serum

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology
Molecular Biology
Cell Biology
Developmental Biology

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https://doi.org/10.1016/j.devcel.2019.01.003

Cite this

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title = "Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency",

abstract = "Pluripotent embryonic stem cells are considered to have open and accessible chromatin relative to differentiated cells. Schlesinger and Meshorer review chromatin and epigenetic features in 2i- versus serum-grown conditions to come to a clearer picture of the genuine characteristics of pluripotency as opposed to artifacts of culture condition.",

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AB - Pluripotent embryonic stem cells are considered to have open and accessible chromatin relative to differentiated cells. Schlesinger and Meshorer review chromatin and epigenetic features in 2i- versus serum-grown conditions to come to a clearer picture of the genuine characteristics of pluripotency as opposed to artifacts of culture condition.

KW - 2i

KW - chromatin

KW - chromatin plasticity

KW - differentiation

KW - embryonic stem cells

KW - epigenetics

KW - ground state

KW - naive

KW - nuclear plasticity

KW - pluripotency

KW - serum

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JO - Developmental Cell

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Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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