One-pot total chemical synthesis of human α-synuclein

Bruno Fauvet; Sara M. Butterfield; Jonas Fuks; Ashraf Brik; Hilal A. Lashuel

doi:10.1039/c3cc45353g

One-pot total chemical synthesis of human α-synuclein

Bruno Fauvet, Sara M. Butterfield, Jonas Fuks, Ashraf Brik, Hilal A. Lashuel

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson’s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

Original language	American English
Pages (from-to)	9254-9256
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	81
DOIs	https://doi.org/10.1039/c3cc45353g
State	Published - 17 Sep 2013

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c3cc45353g

Cite this

@article{640449f3a14f479796e98961014775df,

title = "One-pot total chemical synthesis of human α-synuclein",

abstract = "Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson{\textquoteright}s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.",

author = "Bruno Fauvet and Butterfield, \{Sara M.\} and Jonas Fuks and Ashraf Brik and Lashuel, \{Hilal A.\}",

year = "2013",

month = sep,

day = "17",

doi = "10.1039/c3cc45353g",

language = "American English",

volume = "49",

pages = "9254--9256",

number = "81",

}

TY - JOUR

T1 - One-pot total chemical synthesis of human α-synuclein

AU - Fauvet, Bruno

AU - Butterfield, Sara M.

AU - Fuks, Jonas

AU - Brik, Ashraf

AU - Lashuel, Hilal A.

PY - 2013/9/17

Y1 - 2013/9/17

N2 - Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson’s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

AB - Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson’s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

UR - http://www.scopus.com/inward/record.url?scp=84884316724&partnerID=8YFLogxK

U2 - 10.1039/c3cc45353g

DO - 10.1039/c3cc45353g

M3 - Article

C2 - 23995579

SN - 1359-7345

VL - 49

SP - 9254

EP - 9256

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

One-pot total chemical synthesis of human α-synuclein

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this