One load to rule them all: Mechanical control of the musculoskeletal system in development and aging

Yulia Shwartz, Einat Blitz, Elazar Zelzer

Research output: Contribution to journalArticlepeer-review

Abstract

The musculoskeletal system functions because of the precise and coordinated assembly of its components, namely bones and joints, muscles, tendons and ligaments. This coordination requires cross-talk between the tissues, which is mediated by various molecular and mechanical cues. In this review, we summarize the progress that has been made in understanding the involvement of mechanical loads exerted by the musculature in the development of skeletal and tendinous tissues, in their integration into one functional unit and in the maintenance of this system. In addition, we discuss the possible role of muscle load in aging and propose new directions for future studies of the musculoskeletal system.

Original languageEnglish
Pages (from-to)104-111
Number of pages8
JournalDifferentiation
Volume86
Issue number3
DOIs
StatePublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cancer Research
  • Cell Biology
  • Developmental Biology

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