On the role of membrane anisotropy and BAR proteins in the stability of tubular membrane structures

Doron Kabaso, Nataliya Bobrovska, Wojciech Gozdz, Nir Gov, Veronika Kralj-Iglic, Peter Veranic, Ales Iglic

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies have demonstrated that actin filaments are not crucial for the short-term stability of tubular membrane protrusions originating from the cell surface. It has also been demonstrated that prominin nanodomains and curvature inducing I-BAR proteins could account for the stability of the membrane protrusion. Here we constructed an axisymmetric model of a membrane protrusion that excludes actin filaments in order to investigate the contributions of prominin nanodomains (rafts) and I-BAR proteins to the membrane protrusion stability. It was demonstrated that prominin nanodomains and I-BAR proteins can stabilize the membrane protrusion only over a specific range of spontaneous curvature. On the other hand, high spontaneous curvature and/or high density of I-BAR proteins could lead to system instability and to non-uniform contraction in the radial direction of the membrane protrusion. In agreement with previous studies, it was also shown that the isotropic bending energy of lipids is not sufficient to explain the stability of the observed tubular membrane protrusion without actin filaments.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalJournal of Biomechanics
Volume45
Issue number2
DOIs
StatePublished - 10 Jan 2012

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Rehabilitation
  • Biomedical Engineering
  • Orthopedics and Sports Medicine

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