@article{3f19f8a15a224699bc8b88aa9cffeacb,
title = "On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms",
abstract = "Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction- selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs.",
author = "Sun, {Lu O.} and Zheng Jiang and Michal Rivlin-Etzion and Randal Hand and Brady, {Colleen M.} and Matsuoka, {Ryota L.} and King-Wai Yau and Feller, {Marla B.} and Kolodkin, {Alex L.}",
note = "We thank D. Ginty for the ROSALSL-Tdtomato mice, J. Nathans for Six3-cre, ChAT::cre, ChAT::creER, and ROSAiAP mice, and Y. Yoshida for the Sema6B−/− and Sema6C−/−;6D−/− eyes. We also thank S. Hattar, M. Riccomagno, and Q. Wang for comments on the manuscript and all Kolodkin laboratory members for assistance and discussions throughout the course of this project. This work was supported by NS35165 (A.L.K.); EY06837 (K.-W.Y.); EY019498 and EY013528 (M.B.F.); and the Human Frontier Science Program Organization, the National Postdoctoral Award Program for Advancing Women in Science, and the Edmond and Lily Safra (ELSC) Fellowship for postdoctoral training in Brain Science (M.R.-E.). A.L.K. is an investigator of the Howard Hughes Medical Institute.",
year = "2013",
month = nov,
day = "1",
doi = "https://doi.org/10.1126/science.1241974",
language = "الإنجليزيّة",
volume = "342",
pages = "590--599",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6158",
}