TY - JOUR
T1 - Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems
AU - Rutenberg, Roi
AU - Galaktionova, Daria
AU - Golden, Gilad
AU - Cohen, Yael
AU - Levi-Kalisman, Yael
AU - Cohen, Guy
AU - Král, Petr
AU - Poverenov, Elena
N1 - Funding Information: This research was supported by the Chief Scientist of the Israeli Ministry of Agriculture, grant no. 421-0383-18. Contribution from the Agricultural Research Organization, The Volcani Center, no 815/18. The study was also partially supported by the Ministry of Science and Technology, Israel. P.K. was supported by the NSF-DMR grant 1506886. The authors would like to thank Eduard Belausov for CLSM imaging and analysis. Funding Information: This research was supported by the Chief Scientist of the Israeli Ministry of Agriculture, grant no. 421-0383-18. Contribution from the Agricultural Research Organization The Volcani Center, no 815/18. The study was also partially supported by the Ministry of Science and Technology, Israel. P.K. was supported by the NSF-DMR grant 1506886. The authors would like to thank Eduard Belausov for CLSM imaging and analysis. Publisher Copyright: © 2018 American Chemical Society.
PY - 2018/10/31
Y1 - 2018/10/31
N2 - Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics.
AB - Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics.
KW - atomistic molecular dynamics simulations
KW - cross-phase delivery
KW - omniphilic
KW - pH responsive release
KW - polysaccharide
KW - self-assembly
UR - http://www.scopus.com/inward/record.url?scp=85055289035&partnerID=8YFLogxK
U2 - https://doi.org/10.1021/acsami.8b12855
DO - https://doi.org/10.1021/acsami.8b12855
M3 - Article
C2 - 30285412
SN - 1944-8244
VL - 10
SP - 36711
EP - 36720
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
IS - 43
ER -