Oligonucleotide-based therapy for neurodegenerative diseases

Iddo Magen, Eran Hornstein

Research output: Contribution to journalArticlepeer-review

Abstract

Molecular genetics insight into the pathogenesis of several neurodegenerative diseases, such as Alzheimers disease, Parkinsons disease, Huntingtons disease and amyotrophic lateral sclerosis, encourages direct interference with the activity of neurotoxic genes or the molecular activation of neuroprotective pathways. Oligonucleotide-based therapies are recently emerging as an efficient strategy for drug development and these can be employed as new treatments of neurodegenerative states. Here we review advances in this field in recent years which suggest an encouraging assessment that oligonucleotide technologies for targeting of RNAs will enable the development of new therapies and will contribute to preservation of brain integrity. This article is part of a Special Issue entitled RNA Metabolism 2013.

Original languageEnglish
Pages (from-to)116-128
Number of pages13
JournalBrain Research
Volume1584
DOIs
StatePublished - 10 Oct 2014

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Molecular Biology
  • General Neuroscience
  • Developmental Biology

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