Nucleoside 5’-Phosphorothioate Analogues and Uses Thereof

B Fischer (Inventor), S Azran (Inventor), O Danino (Inventor)

Research output: Patent


The invention provides particular mono- and dinucleoside 5'-phosphorothioate analogues, more particularly mono- or di- adenosine or uridine 5'-di- or tri- phosphorothioate analogues in which at least one of the bridging oxygen atoms of the phosphorothioate is replaced by a group such as -CH2-, and at least one of the non- bridging atoms or negatively-charged atoms of the phosphorothioate is either a sulfur atom or a sulfur ion; and pharmaceutical compositions thereof. These compounds are useful for treatment of neurodegenerative diseases or disorders such as Alzheimer's disease.
Original languageAmerican English
Patent numberPCT/IL2013/050202
Priority date5/03/12
Filing date5/03/12
StatePublished - 2013


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