Nuclear imaging in mechanobiology

Irena L. Ivanovska; Joe Swift; Jerome Irianto; Kyle Spinler; Jae Won Shin; Amnon Buxboim; Dennis E. Discher

doi:10.1201/b17566

Nuclear imaging in mechanobiology

Irena L. Ivanovska, Joe Swift, Jerome Irianto, Kyle Spinler, Jae Won Shin, Amnon Buxboim, Dennis E. Discher

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

All of the different cells within an individual share the same genome, whereas epigenetic variations underlie the plasticity in gene expression from the stem cells that differentiate during development, repair, and aging. Beyond differences in covalent and noncovalent modifications of chromatin between different cell types, there are also lineage-relevant variations in the structure proteins of the nuclear envelope called lamins that contribute to chromatin organization and even transcription factor localization. Here we focus on imaging these various molecular factors with the relevant optical microscopy in the context of multiple methods for physically manipulating nuclei.

Original language	English
Title of host publication	Handbook of Imaging in Biological Mechanics
Pages	401-413
Number of pages	13
ISBN (Electronic)	9781466588141
DOIs	https://doi.org/10.1201/b17566
State	Published - 1 Jan 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine
General Biochemistry,Genetics and Molecular Biology
General Engineering
General Physics and Astronomy

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AU - Discher, Dennis E.

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Nuclear imaging in mechanobiology

Abstract

All Science Journal Classification (ASJC) codes

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