Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Lena Trifonov; Katerina Chumin; Raanan Gvirtz; Michal Afri; Edward E. Korshin; Guy Cohen; Arie Gruzman

doi:10.1016/j.mencom.2020.11.006

Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Lena Trifonov, Katerina Chumin, Raanan Gvirtz, Michal Afri, Edward E. Korshin, Guy Cohen, Arie Gruzman

Department of Chemistry

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.

Original language	English
Pages (from-to)	709-711
Number of pages	3
Journal	Mendeleev Communications
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.mencom.2020.11.006
State	Published - 1 Nov 2020

Keywords

Malassezia furfur
arenesulfonamides
fungicides
medicinal chemistry
seborrheic dermatitis

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1016/j.mencom.2020.11.006

Cite this

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title = "Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur",

abstract = "Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.",

keywords = "Malassezia furfur, arenesulfonamides, fungicides, medicinal chemistry, seborrheic dermatitis",

author = "Lena Trifonov and Katerina Chumin and Raanan Gvirtz and Michal Afri and Korshin, \{Edward E.\} and Guy Cohen and Arie Gruzman",

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doi = "10.1016/j.mencom.2020.11.006",

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T1 - Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

AU - Trifonov, Lena

AU - Chumin, Katerina

AU - Gvirtz, Raanan

AU - Afri, Michal

AU - Korshin, Edward E.

AU - Cohen, Guy

AU - Gruzman, Arie

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.

AB - Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.

KW - Malassezia furfur

KW - arenesulfonamides

KW - fungicides

KW - medicinal chemistry

KW - seborrheic dermatitis

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DO - 10.1016/j.mencom.2020.11.006

M3 - مقالة

SN - 0959-9436

VL - 30

SP - 709

EP - 711

JO - Mendeleev Communications

JF - Mendeleev Communications

IS - 6

ER -

Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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