Novel mannitol-based small molecules for inhibiting aggregation of α-synuclein amyloids in Parkinson's disease

Keyphrases

• Parkinson's Disease 100%
• Small Molecules 100%
• Mannitol 100%
• Alpha-synuclein (α-syn) 100%
• Tryptophan 50%
• Naphthoquinone 50%
• Therapeutic Agents 25%
• Conjugation 25%
• Transmission Electron Microscopy 25%
• Linker 25%
• Neuroblastoma Cells 25%
• Neuroblastoma SH-SY5Y Cells 25%
• Artificial Membrane 25%
• Reduced Toxicity 25%
• Amyloid Protein 25%
• Birefringence 25%
• Circular Dichroism 25%
• Large Unilamellar Vesicles 25%
• Congo Red 25%
• Disruptive Effect 25%
• Low Cytotoxicity 25%
• Thioflavin T 25%
• Dye Leakage 25%
• Leak Test 25%
• Toxic Oligomers 25%
• PEG Linker 25%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Amyloid Protein 100%
• Mannitol 100%
• Synuclein 100%
• Tryptophan 66%
• Conjugate 66%
• Cytotoxicity 33%
• Transmission Electron Microscopy 33%
• Fluorescence Assay 33%
• Circular Dichroism 33%
• Click 33%
• Thioflavin 33%
• Artificial Membrane 33%
• Congo Red 33%
• Birefringence 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Parkinson's Disease 100%
• Amyloid Protein 100%
• Mannitol 100%
• Synuclein 100%
• Tryptophan 50%
• Naphthoquinone 50%
• Cytotoxicity 25%
• Neuroblastoma 25%
• Oligomer 25%
• Transmission Electron Microscopy 25%
• Fluorescence Assay 25%
• Polyethylene Glycol 25%
• Thioflavine 25%
• Congo Red 25%