NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS

Timor Baasov; Tamar Ben-Yosef; Igor Nudelman; Annie Rebibo-Sabbah; Dalia Shallom-Shezifi; Mariana Hainrichson

NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS

Timor Baasov (Inventor), Tamar Ben-Yosef (Inventor), Igor Nudelman (Inventor), Annie Rebibo-Sabbah (Inventor), Dalia Shallom-Shezifi (Inventor), Mariana Hainrichson (Inventor)

Technion - Israel Institute of Technology

Research output: Patent

Abstract

A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

Original language	American English
Patent number	US2019060340 AA
IPC	C07H 5/ 06 A I
Priority date	14/11/18
State	Published - 28 Feb 2019

Cite this

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title = "NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS",

abstract = "A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.",

author = "Timor Baasov and Tamar Ben-Yosef and Igor Nudelman and Annie Rebibo-Sabbah and Dalia Shallom-Shezifi and Mariana Hainrichson",

year = "2019",

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language = "American English",

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AU - Baasov, Timor

AU - Ben-Yosef, Tamar

AU - Nudelman, Igor

AU - Rebibo-Sabbah, Annie

AU - Shallom-Shezifi, Dalia

AU - Hainrichson, Mariana

PY - 2019/2/28

Y1 - 2019/2/28

N2 - A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

AB - A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

M3 - Patent

M1 - US2019060340 AA

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