NON-CYTOTOXIC MODIFIED CELLS AND USE THEREOF

Alon Monsonego; Angel Porgador; Roee Atlas

NON-CYTOTOXIC MODIFIED CELLS AND USE THEREOF

Alon Monsonego (Inventor), Angel Porgador (Inventor), Roee Atlas (Inventor)

The Shraga Segal Department of Microbiology and Immunology

Ben-Gurion University of the Negev

Research output: Patent

Abstract

Modified cells comprising a transmembrane polypeptide comprising at least one extracellular target receptor-binding domain, a transmembrane domain and an intracellular domain, wherein said intracellular domain is not capable of transducing any signal are provided. Methods of inducing or inhibiting signaling by a target receptor in a target cell comprising contacting the target cell with a modified cell of the invention are also provided.

Original language	American English
Patent number	WO2018069927
IPC	C12N 5/ 10 A I
Priority date	10/10/16
State	Published - 19 Apr 2018

Cite this

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title = "NON-CYTOTOXIC MODIFIED CELLS AND USE THEREOF",

abstract = "Modified cells comprising a transmembrane polypeptide comprising at least one extracellular target receptor-binding domain, a transmembrane domain and an intracellular domain, wherein said intracellular domain is not capable of transducing any signal are provided. Methods of inducing or inhibiting signaling by a target receptor in a target cell comprising contacting the target cell with a modified cell of the invention are also provided.",

author = "Alon Monsonego and Angel Porgador and Roee Atlas",

year = "2018",

month = apr,

day = "19",

language = "American English",

type = "Patent",

note = "WO2018069927; C12N 5/ 10 A I",

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TY - PAT

T1 - NON-CYTOTOXIC MODIFIED CELLS AND USE THEREOF

AU - Monsonego, Alon

AU - Porgador, Angel

AU - Atlas, Roee

PY - 2018/4/19

Y1 - 2018/4/19

N2 - Modified cells comprising a transmembrane polypeptide comprising at least one extracellular target receptor-binding domain, a transmembrane domain and an intracellular domain, wherein said intracellular domain is not capable of transducing any signal are provided. Methods of inducing or inhibiting signaling by a target receptor in a target cell comprising contacting the target cell with a modified cell of the invention are also provided.

AB - Modified cells comprising a transmembrane polypeptide comprising at least one extracellular target receptor-binding domain, a transmembrane domain and an intracellular domain, wherein said intracellular domain is not capable of transducing any signal are provided. Methods of inducing or inhibiting signaling by a target receptor in a target cell comprising contacting the target cell with a modified cell of the invention are also provided.

M3 - Patent

M1 - WO2018069927

ER -

NON-CYTOTOXIC MODIFIED CELLS AND USE THEREOF

Abstract

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