NMR characterization of a Cu(i)-bound peptide model of copper metallochaperones: Insights on the role of methionine

Michal S. Shoshan; Deborah E. Shalev; Wencke Adriaens; Maarten Merkx; Tilman M. Hackeng; Edit Y. Tshuva

doi:10.1039/c1cc11600b

NMR characterization of a Cu(i)-bound peptide model of copper metallochaperones: Insights on the role of methionine

Michal S. Shoshan, Deborah E. Shalev, Wencke Adriaens, Maarten Merkx, Tilman M. Hackeng, Edit Y. Tshuva

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

The first NMR structure of a Cu(i)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH ∼3.0 and ∼6.8 Cu(i) binds through one Cys and the Met rather than the two Cys residues, differently than at pH ∼8.5. This suggests a possible role of Met in metal transport.

Original language	English
Pages (from-to)	6407-6409
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	22
DOIs	https://doi.org/10.1039/c1cc11600b
State	Published - 14 Jun 2011

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc11600b

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title = "NMR characterization of a Cu(i)-bound peptide model of copper metallochaperones: Insights on the role of methionine",

abstract = "The first NMR structure of a Cu(i)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH ∼3.0 and ∼6.8 Cu(i) binds through one Cys and the Met rather than the two Cys residues, differently than at pH ∼8.5. This suggests a possible role of Met in metal transport.",

author = "Shoshan, \{Michal S.\} and Shalev, \{Deborah E.\} and Wencke Adriaens and Maarten Merkx and Hackeng, \{Tilman M.\} and Tshuva, \{Edit Y.\}",

year = "2011",

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day = "14",

doi = "10.1039/c1cc11600b",

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T1 - NMR characterization of a Cu(i)-bound peptide model of copper metallochaperones

T2 - Insights on the role of methionine

AU - Shoshan, Michal S.

AU - Shalev, Deborah E.

AU - Adriaens, Wencke

AU - Merkx, Maarten

AU - Hackeng, Tilman M.

AU - Tshuva, Edit Y.

PY - 2011/6/14

Y1 - 2011/6/14

N2 - The first NMR structure of a Cu(i)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH ∼3.0 and ∼6.8 Cu(i) binds through one Cys and the Met rather than the two Cys residues, differently than at pH ∼8.5. This suggests a possible role of Met in metal transport.

AB - The first NMR structure of a Cu(i)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH ∼3.0 and ∼6.8 Cu(i) binds through one Cys and the Met rather than the two Cys residues, differently than at pH ∼8.5. This suggests a possible role of Met in metal transport.

UR - http://www.scopus.com/inward/record.url?scp=79957525383&partnerID=8YFLogxK

U2 - 10.1039/c1cc11600b

DO - 10.1039/c1cc11600b

M3 - مقالة

C2 - 21552638

SN - 1359-7345

VL - 47

SP - 6407

EP - 6409

JO - Chemical Communications

JF - Chemical Communications

IS - 22

ER -

NMR characterization of a Cu(i)-bound peptide model of copper metallochaperones: Insights on the role of methionine

Abstract

All Science Journal Classification (ASJC) codes

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