NIX-ing mitochondria: from development to pathology

Aleksandra Deczkowska, Michal Schwartz

Research output: Contribution to journalComment/debatepeer-review


Hypoxia occurs physiologically in the developing body, and changing oxygen tensions are known to direct tissue differentiation; however, in the context of pathology, the same hypoxia-activated mechanisms may negatively affect tissue function. In this issue of The EMBO Journal, Esteban-Martinez et al (2017) report that programmed mitophagy, dependent on hypoxia-induced NIP-3-like protein X (BNIP3L, best known as NIX), is an essential step in differentiation of both retinal neurons and inflammatory macrophages.
Original languageEnglish
Pages (from-to)1650-1652
Number of pages3
JournalThe EMBO Journal
Issue number12
StatePublished - 14 Jun 2017

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • General Biochemistry,Genetics and Molecular Biology
  • Molecular Biology
  • General Neuroscience


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