Nitric Oxide Sensing through Azo-Dye Formation on Carbon Dots

Sagarika Bhattacharya, Rhitajit Sarkar, Biswarup Chakraborty, Angel Porgador, Raz Jelinek

Research output: Contribution to journalArticlepeer-review


Carbon dots (C-dots) prepared through heating of aminoguanidine and citric acid enable bimodal (colorimetric and fluorescence) detection of nitric oxide (NO) in aqueous solutions. The C-dots retained the functional units of aminoguanidine, which upon reaction with NO produced surface residues responsible for the color and fluorescence transformations. Notably, the aminoguanidine/citric acid C-dots were noncytotoxic, making possible real-time and high sensitivity detection of NO in cellular environments. Using multiprong spectroscopic and chromatography analyses we deciphered the molecular mechanism accounting for the NO-induced structural and photophysical transformations of the C-dots, demonstrating for the first time N2 release and azo dye formation upon the C-dots' surface.

Original languageAmerican English
Pages (from-to)1215-1224
Number of pages10
JournalACS Sensors
Issue number8
StatePublished - 25 Aug 2017


  • azo dye formation
  • carbon dots
  • fluorescence quenching
  • nitric oxide detection
  • polymerization of C-dots

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Instrumentation
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes


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