New anti-inflammatory mechanism of glucocorticoids uncovered

Carolyn L. Cummins; Ido Goldstein

doi:10.1016/j.tem.2024.08.003

New anti-inflammatory mechanism of glucocorticoids uncovered

Carolyn L. Cummins, Ido Goldstein

Institute of Biochemistry, Food Science and Nutrition

The Hebrew University of Jerusalem

Research output: Contribution to journal › Short survey › peer-review

Abstract

Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.

Original language	English
Pages (from-to)	99-101
Number of pages	3
Journal	Trends in Endocrinology and Metabolism
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.tem.2024.08.003
State	Published - Feb 2025

Keywords

GR
LPS
PDH
itaconate
macrophage

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2024.08.003

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abstract = "Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.",

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AB - Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.

KW - GR

KW - LPS

KW - PDH

KW - itaconate

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ER -

New anti-inflammatory mechanism of glucocorticoids uncovered

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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