Neuronal plasticity features are independent of neuronal holding membrane potential

Roni Vardi; Yael Tugendhaft; Ido Kanter

doi:10.1016/j.physa.2023.129351

Neuronal plasticity features are independent of neuronal holding membrane potential

Roni Vardi, Yael Tugendhaft, Ido Kanter

Department of Physics - at Bar-Ilan University

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Dynamical reversible neuronal features in vitro are typically examined using a fixed holding membrane potential, imitating the physiological conditions of intact brains in an awake state. Here, a set of neuronal plasticity features in synaptic blocked cultures are found to be independent of the holding membrane potential in the range [−95, −50] mV. Specifically, dendritic maximal firing frequency and its absolute refractory period are independent of the holding membrane potential. In addition, the stimulation threshold is also independent of the holding membrane potential in neurons that do not show membrane depolarization in response to sub-threshold stimulations. These robust dendritic plasticity features are a prerequisite for neuronal modeling and for their utilization in interconnected neural networks to realize higher-order functionalities.

Original language	English
Article number	129351
Journal	Physica A: Statistical Mechanics and its Applications
Volume	632
DOIs	https://doi.org/10.1016/j.physa.2023.129351
State	Published - 15 Dec 2023

Keywords

Dendritic learning
Neuronal plasticity
Reversible processes

All Science Journal Classification (ASJC) codes

Statistical and Nonlinear Physics
Statistics and Probability

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10.1016/j.physa.2023.129351

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title = "Neuronal plasticity features are independent of neuronal holding membrane potential",

abstract = "Dynamical reversible neuronal features in vitro are typically examined using a fixed holding membrane potential, imitating the physiological conditions of intact brains in an awake state. Here, a set of neuronal plasticity features in synaptic blocked cultures are found to be independent of the holding membrane potential in the range [−95, −50] mV. Specifically, dendritic maximal firing frequency and its absolute refractory period are independent of the holding membrane potential. In addition, the stimulation threshold is also independent of the holding membrane potential in neurons that do not show membrane depolarization in response to sub-threshold stimulations. These robust dendritic plasticity features are a prerequisite for neuronal modeling and for their utilization in interconnected neural networks to realize higher-order functionalities.",

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T1 - Neuronal plasticity features are independent of neuronal holding membrane potential

AU - Vardi, Roni

AU - Tugendhaft, Yael

AU - Kanter, Ido

PY - 2023/12/15

Y1 - 2023/12/15

N2 - Dynamical reversible neuronal features in vitro are typically examined using a fixed holding membrane potential, imitating the physiological conditions of intact brains in an awake state. Here, a set of neuronal plasticity features in synaptic blocked cultures are found to be independent of the holding membrane potential in the range [−95, −50] mV. Specifically, dendritic maximal firing frequency and its absolute refractory period are independent of the holding membrane potential. In addition, the stimulation threshold is also independent of the holding membrane potential in neurons that do not show membrane depolarization in response to sub-threshold stimulations. These robust dendritic plasticity features are a prerequisite for neuronal modeling and for their utilization in interconnected neural networks to realize higher-order functionalities.

AB - Dynamical reversible neuronal features in vitro are typically examined using a fixed holding membrane potential, imitating the physiological conditions of intact brains in an awake state. Here, a set of neuronal plasticity features in synaptic blocked cultures are found to be independent of the holding membrane potential in the range [−95, −50] mV. Specifically, dendritic maximal firing frequency and its absolute refractory period are independent of the holding membrane potential. In addition, the stimulation threshold is also independent of the holding membrane potential in neurons that do not show membrane depolarization in response to sub-threshold stimulations. These robust dendritic plasticity features are a prerequisite for neuronal modeling and for their utilization in interconnected neural networks to realize higher-order functionalities.

KW - Dendritic learning

KW - Neuronal plasticity

KW - Reversible processes

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U2 - 10.1016/j.physa.2023.129351

DO - 10.1016/j.physa.2023.129351

M3 - مقالة

SN - 0378-4371

VL - 632

JO - Physica A: Statistical Mechanics and its Applications

JF - Physica A: Statistical Mechanics and its Applications

M1 - 129351

ER -

Neuronal plasticity features are independent of neuronal holding membrane potential

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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