Network Modeling of Tissues and Cell Types

Maya Ziv; Esti Yeger-Lotem

doi:https://doi.org/10.1016/B978-0-12-821618-7.00235-2

Network Modeling of Tissues and Cell Types

Maya Ziv, Esti Yeger-Lotem

Department of Clinical Biochemistry and Pharmacology

Ben-Gurion University of the Negev

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

Abstract

All cellular processes, from cell growth and proliferation to metabolism and cell death, involve biochemical interactions among genes, proteins, RNA, metabolites, and other molecules. In specific cellular contexts, such as within a cellular compartment, cell type, or tissue, certain molecular interactions occur whereas other interactions are avoided, resulting in distinct cellular processes, functions and phenotypes. Network concepts, algorithms and tools allow for modeling and predicting how the molecular interactions combine into cellular processes in distinct contexts. This article presents network approaches and their application to the modeling of tissues and cell types, with particular emphasis on modeling human tissues.

Original language	American English
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Systems, Translational and Specialized Cell Aspects of Cell Biology
Publisher	Elsevier
Pages	444-453
Number of pages	10
Volume	6
Edition	Second Edition
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00235-2
State	Published - 2023

Keywords

Bioinformatics
Data Integration
Gene Expression
Human Tissues
Interaction Networks
Network Biology
Protein-Protein Interactions
RNA Sequencing
Single Cell
Tissue Specificity

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Access to Document

https://doi.org/10.1016/B978-0-12-821618-7.00235-2

Cite this

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title = "Network Modeling of Tissues and Cell Types",

abstract = "All cellular processes, from cell growth and proliferation to metabolism and cell death, involve biochemical interactions among genes, proteins, RNA, metabolites, and other molecules. In specific cellular contexts, such as within a cellular compartment, cell type, or tissue, certain molecular interactions occur whereas other interactions are avoided, resulting in distinct cellular processes, functions and phenotypes. Network concepts, algorithms and tools allow for modeling and predicting how the molecular interactions combine into cellular processes in distinct contexts. This article presents network approaches and their application to the modeling of tissues and cell types, with particular emphasis on modeling human tissues.",

keywords = "Bioinformatics, Data Integration, Gene Expression, Human Tissues, Interaction Networks, Network Biology, Protein-Protein Interactions, RNA Sequencing, Single Cell, Tissue Specificity",

author = "Maya Ziv and Esti Yeger-Lotem",

note = "This is an update of E. Fraenkel, M.I. Koeva, Network Modeling of Heterogeneous Datasets edited by Ralph A. Bradshaw, Philip D. Stahl, Encyclopedia of Cell Biology, Academic Press, 2016, Pages 211–217.",

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AU - Yeger-Lotem, Esti

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AB - All cellular processes, from cell growth and proliferation to metabolism and cell death, involve biochemical interactions among genes, proteins, RNA, metabolites, and other molecules. In specific cellular contexts, such as within a cellular compartment, cell type, or tissue, certain molecular interactions occur whereas other interactions are avoided, resulting in distinct cellular processes, functions and phenotypes. Network concepts, algorithms and tools allow for modeling and predicting how the molecular interactions combine into cellular processes in distinct contexts. This article presents network approaches and their application to the modeling of tissues and cell types, with particular emphasis on modeling human tissues.

KW - Bioinformatics

KW - Data Integration

KW - Gene Expression

KW - Human Tissues

KW - Interaction Networks

KW - Network Biology

KW - Protein-Protein Interactions

KW - RNA Sequencing

KW - Single Cell

KW - Tissue Specificity

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DO - https://doi.org/10.1016/B978-0-12-821618-7.00235-2

M3 - Entry for encyclopedia/dictionary

VL - 6

SP - 444

EP - 453

BT - Encyclopedia of Cell Biology

PB - Elsevier

ER -

Network Modeling of Tissues and Cell Types

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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