NEET proteins as novel drug targets for mitochondrial dysfunction

Henri Baptiste Marjault; Ke Zuo; Ron Mittler; Paolo Carloni; Rachel Nechushtai

doi:10.1016/B978-0-12-819621-2.00021-8

NEET proteins as novel drug targets for mitochondrial dysfunction

Henri Baptiste Marjault
, Ke Zuo
, Ron Mittler
, Paolo Carloni
, Rachel Nechushtai

Department of Plant and Environmental Sciences (Natural Sciences)

The Hebrew University of Jerusalem

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

NEET proteins belong to a newly discovered class of iron-sulfur proteins that harbor a unique labile [2Fe-2S] cluster and is thought to play a major role in preventing mitochondrial dysfunction. Mitochondrial dysfunction is associated with many human pathologies including diabetes, inflammation, neurodegeneration, and cancer. The degree of NEET [2Fe-2S] cluster stability was recently shown to affect mitochondrial function. Nevertheless, only a few compounds have thus far been discovered or designed as NEET ligands that control NEET [2Fe-2S] stability. This chapter summarizes the role of NEET proteins in different diseases and highlights the need to develop additional NEET ligands with a high therapeutic potential.

Original language	English
Title of host publication	Clinical Bioenergetics
Subtitle of host publication	From Pathophysiology to Clinical Translation
Publisher	Elsevier
Pages	477-488
Number of pages	12
ISBN (Electronic)	9780128196212
DOIs	https://doi.org/10.1016/B978-0-12-819621-2.00021-8
State	Published - 1 Jan 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cluster lability
Drug design
Iron-sulfur proteins
Mitochondrial dysfunction
NEET proteins

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.1016/B978-0-12-819621-2.00021-8

Cite this

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abstract = "NEET proteins belong to a newly discovered class of iron-sulfur proteins that harbor a unique labile [2Fe-2S] cluster and is thought to play a major role in preventing mitochondrial dysfunction. Mitochondrial dysfunction is associated with many human pathologies including diabetes, inflammation, neurodegeneration, and cancer. The degree of NEET [2Fe-2S] cluster stability was recently shown to affect mitochondrial function. Nevertheless, only a few compounds have thus far been discovered or designed as NEET ligands that control NEET [2Fe-2S] stability. This chapter summarizes the role of NEET proteins in different diseases and highlights the need to develop additional NEET ligands with a high therapeutic potential.",

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AU - Marjault, Henri Baptiste

AU - Zuo, Ke

AU - Mittler, Ron

AU - Carloni, Paolo

AU - Nechushtai, Rachel

PY - 2020/1/1

Y1 - 2020/1/1

N2 - NEET proteins belong to a newly discovered class of iron-sulfur proteins that harbor a unique labile [2Fe-2S] cluster and is thought to play a major role in preventing mitochondrial dysfunction. Mitochondrial dysfunction is associated with many human pathologies including diabetes, inflammation, neurodegeneration, and cancer. The degree of NEET [2Fe-2S] cluster stability was recently shown to affect mitochondrial function. Nevertheless, only a few compounds have thus far been discovered or designed as NEET ligands that control NEET [2Fe-2S] stability. This chapter summarizes the role of NEET proteins in different diseases and highlights the need to develop additional NEET ligands with a high therapeutic potential.

AB - NEET proteins belong to a newly discovered class of iron-sulfur proteins that harbor a unique labile [2Fe-2S] cluster and is thought to play a major role in preventing mitochondrial dysfunction. Mitochondrial dysfunction is associated with many human pathologies including diabetes, inflammation, neurodegeneration, and cancer. The degree of NEET [2Fe-2S] cluster stability was recently shown to affect mitochondrial function. Nevertheless, only a few compounds have thus far been discovered or designed as NEET ligands that control NEET [2Fe-2S] stability. This chapter summarizes the role of NEET proteins in different diseases and highlights the need to develop additional NEET ligands with a high therapeutic potential.

KW - Cluster lability

KW - Drug design

KW - Iron-sulfur proteins

KW - Mitochondrial dysfunction

KW - NEET proteins

UR - https://www.scopus.com/pages/publications/85123883326

U2 - 10.1016/B978-0-12-819621-2.00021-8

DO - 10.1016/B978-0-12-819621-2.00021-8

M3 - فصل

SP - 477

EP - 488

BT - Clinical Bioenergetics

PB - Elsevier

ER -

NEET proteins as novel drug targets for mitochondrial dysfunction

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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