Abstract
NKp46/NCR1 is an activating NK-cell receptor implicated in the control of various viral and bacterial infections. Recent findings also suggest that it plays a role in shaping the adaptive immune response to pathogens. Using NCR1-deficient (NCR1gfp/gfp) mice, we provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection (MCMV). The absence of NCR1 resulted in impaired maturation, function and NK-cell migration to regional lymph nodes. In addition, CD4+ T-cell activation and follicular helper T-cell (Tfh) generation were reduced, leading to inferior germinal center (GC) B-cell maturation. As a consequence, NCR1gfp/gfp mice produced lower amounts of MCMV-specific antibodies upon infection, which correlated with lower number of virus-specific antibody secreting cells in analyzed lymph nodes.
Original language | English |
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Pages (from-to) | 1443-1456 |
Number of pages | 14 |
Journal | European Journal of Immunology |
Volume | 47 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2017 |
Keywords
- Antiviral antibodies
- Follicular helper T cells
- Germinal center B cells
- NCR1 receptor
- NK-cell immunoregulation
- Viral infection
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology