Natural killers of cognition

Nurit Papismadov; Valery Krizhanovsky

doi:10.1038/s41593-020-00749-6

Natural killers of cognition

Nurit Papismadov
, Valery Krizhanovsky

Department of Molecular Cell Biology

Weizmann Institute of Science

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

One of the mechanisms driving aging and neurodegenerative diseases is the accumulation of senescent cells, while their elimination mitigates age-related decline. A new report details how, with aging, changes in the dentate gyrus microenvironment lead to natural-killer-cell-mediated clearance of neurogenic senescent cells, resulting in cognitive decline.

Original language	English
Pages (from-to)	2-4
Number of pages	3
Journal	Nature Neuroscience
Volume	24
Issue number	1
Early online date	30 Nov 2020
DOIs	https://doi.org/10.1038/s41593-020-00749-6
State	Published - Jan 2021

ASJC Scopus subject areas

General Neuroscience

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10.1038/s41593-020-00749-6

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abstract = "One of the mechanisms driving aging and neurodegenerative diseases is the accumulation of senescent cells, while their elimination mitigates age-related decline. A new report details how, with aging, changes in the dentate gyrus microenvironment lead to natural-killer-cell-mediated clearance of neurogenic senescent cells, resulting in cognitive decline.",

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AB - One of the mechanisms driving aging and neurodegenerative diseases is the accumulation of senescent cells, while their elimination mitigates age-related decline. A new report details how, with aging, changes in the dentate gyrus microenvironment lead to natural-killer-cell-mediated clearance of neurogenic senescent cells, resulting in cognitive decline.

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Natural killers of cognition

Abstract

ASJC Scopus subject areas

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