Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis

Roni Scherzer; Ehud Gazit; Daniel Segal

Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis

Roni Scherzer (Inventor), Ehud Gazit (Inventor), Daniel Segal (Inventor)

Biotechnology

Tel Aviv University

Research output: Patent

Abstract

The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.

Original language	American English
Patent number	CN102186464
IPC	A61K 31/ 405 A I
Priority date	6/09/09
State	Published - 14 Sep 2011

Cite this

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title = "Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis",

abstract = "The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.",

author = "Roni Scherzer and Ehud Gazit and Daniel Segal",

year = "2011",

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language = "American English",

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T1 - Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis

AU - Scherzer, Roni

AU - Gazit, Ehud

AU - Segal, Daniel

PY - 2011/9/14

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N2 - The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.

AB - The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.

M3 - Patent

M1 - CN102186464

ER -

Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis

Abstract

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