Nanoparticles targeting the infarcted heart

Tal Dvir, Michael Bauer, Avi Schroeder, Jonathan H. Tsui, Daniel G. Anderson, Robert Langer, Ronglih Liao, Daniel S. Kohane

Research output: Contribution to journalArticlepeer-review

Abstract

We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.

Original languageEnglish
Pages (from-to)4411-4414
Number of pages4
JournalNano Letters
Volume11
Issue number10
DOIs
StatePublished - 12 Oct 2011
Externally publishedYes

Keywords

  • Liposomes
  • anoparticles
  • argeting
  • yocardial infarction

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Condensed Matter Physics
  • Mechanical Engineering
  • Bioengineering
  • General Materials Science

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