Abstract
We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.
Original language | English |
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Pages (from-to) | 4411-4414 |
Number of pages | 4 |
Journal | Nano Letters |
Volume | 11 |
Issue number | 10 |
DOIs | |
State | Published - 12 Oct 2011 |
Externally published | Yes |
Keywords
- Liposomes
- anoparticles
- argeting
- yocardial infarction
All Science Journal Classification (ASJC) codes
- General Chemistry
- Condensed Matter Physics
- Mechanical Engineering
- Bioengineering
- General Materials Science