Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells

Jianmin Xu; Tara Teslaa; Ting Hsiang Wu; Pei Yu Chiou; Michael A. Teitell; Shimon Weiss

doi:10.1021/nl302821g

Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells

Jianmin Xu, Tara Teslaa, Ting Hsiang Wu, Pei Yu Chiou, Michael A. Teitell, Shimon Weiss

Research output: Contribution to journal › Article › peer-review

Abstract

Quantum dots (QDs) have not been used to label cytoskeleton structure of live cells owing to limitations in delivery strategies, and QDs conjugation methods and issues with nonspecific binding. We conjugated tubulin to QDs and applied the emerging method of photothermal nanoblade to deliver QD-tubulin conjugates into live Hela cells. This method will open new opportunities for cytosolic targeting of QDs in live cells.

Original language	English
Pages (from-to)	5669-5672
Number of pages	4
Journal	Nano Letters
Volume	12
Issue number	11
DOIs	https://doi.org/10.1021/nl302821g
State	Published - 14 Nov 2012
Externally published	Yes

Keywords

Nanoblade delivery
QD-tubulin
cytosolic targeting

All Science Journal Classification (ASJC) codes

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl302821g

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title = "Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells",

abstract = "Quantum dots (QDs) have not been used to label cytoskeleton structure of live cells owing to limitations in delivery strategies, and QDs conjugation methods and issues with nonspecific binding. We conjugated tubulin to QDs and applied the emerging method of photothermal nanoblade to deliver QD-tubulin conjugates into live Hela cells. This method will open new opportunities for cytosolic targeting of QDs in live cells.",

keywords = "Nanoblade delivery, QD-tubulin, cytosolic targeting",

author = "Jianmin Xu and Tara Teslaa and Wu, {Ting Hsiang} and Chiou, {Pei Yu} and Teitell, {Michael A.} and Shimon Weiss",

year = "2012",

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doi = "10.1021/nl302821g",

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T1 - Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells

AU - Xu, Jianmin

AU - Teslaa, Tara

AU - Wu, Ting Hsiang

AU - Chiou, Pei Yu

AU - Teitell, Michael A.

AU - Weiss, Shimon

PY - 2012/11/14

Y1 - 2012/11/14

N2 - Quantum dots (QDs) have not been used to label cytoskeleton structure of live cells owing to limitations in delivery strategies, and QDs conjugation methods and issues with nonspecific binding. We conjugated tubulin to QDs and applied the emerging method of photothermal nanoblade to deliver QD-tubulin conjugates into live Hela cells. This method will open new opportunities for cytosolic targeting of QDs in live cells.

AB - Quantum dots (QDs) have not been used to label cytoskeleton structure of live cells owing to limitations in delivery strategies, and QDs conjugation methods and issues with nonspecific binding. We conjugated tubulin to QDs and applied the emerging method of photothermal nanoblade to deliver QD-tubulin conjugates into live Hela cells. This method will open new opportunities for cytosolic targeting of QDs in live cells.

KW - Nanoblade delivery

KW - QD-tubulin

KW - cytosolic targeting

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U2 - 10.1021/nl302821g

DO - 10.1021/nl302821g

M3 - مقالة

C2 - 23094784

SN - 1530-6984

VL - 12

SP - 5669

EP - 5672

JO - Nano Letters

JF - Nano Letters

IS - 11

ER -

Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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