TY - JOUR
T1 - Nanobiotechnology
T2 - Synthetic biology meets materials science
AU - Jewett, Michael C.
AU - Patolsky, Fernando
N1 - Funding Information: Nanotechnology offers great potential in terms of enabling technological advances across a wide range of industries. However, the acceptance of nanotechnology, and hence nano-enabled products, is reliant on public and consumer confidence in their human and environmental safety. Thus, the analysis of nanomaterials hazard is currently a major research concern for toxicologists, since there is a pressing requirement for a comprehensive understanding of potential hazards due to the wide spectrum of nanomaterials composition, shape and size. The Biologically Effective Doses (BED) of nanoparticles, the dose entity that drives toxicity, include charge, solubility, contaminants, shape and the ability to translocate from the site of deposition in the lungs. Therefore, conventional particle toxicology data is useful and relevant to the determination of the nanoparticle hazard. Donaldson and Poland report discusses the general basis of toxicity for nanoparticles. Generally speaking, to understand the basis of toxicity is to understand the driving component, and how this can be a variable entity between materials of the same, as well as differing, physico-chemical characteristics. In summary, the collection of articles in this special section demonstrates the potential for nanobiotechnology for a broad array of applications. We believe that these reviews celebrate recent successes, revealing significant potential for near-term and long-term impact. Moreover, we expect these articles to point to new challenges and opportunities that drive future research and advance the field for years to come. Michael Jewett is an Assistant Professor of Chemical and Biological Engineering at Northwestern University. He received his PhD in 2005 at Stanford University. After completing postdoctoral studies as an NSF International Research Fellow at the Center for Microbial Biotechnology in Denmark and as an NIH Pathway to Independence Fellow at the Harvard Medical School, he joined Northwestern in 2009. Dr. Jewett is developing cell-free biology as an enabling technology for biomanufacturing lifesaving therapeutics, sustainable chemicals, and novel materials, both quickly and on-demand. Fernando Patolsky is an Associate Professor at the department of Chemistry, Tel Aviv University, Israel. He received his PhD from the Hebrew University of Jerusalem, followed by a postdoctoral appointment at Harvard University where he worked in the field of nanobiotechnology. As a young scientist working in the fields of biotechnology and nanobiotechnology, Fernando's research is focused on the development of molecular and biomolecular electronic systems, aiming to establish fundamental principles for the construction of novel optical and electronic sensors and biosensors. These scientific activities represent a leading interdisciplinary effort to bridge chemistry, biology and materials science.
PY - 2013/8
Y1 - 2013/8
N2 - Nanotechnology, the area of science focused on the control of matter in the nanometer scale, allows ground-breaking changes of the fundamental properties of matter that are often radically different compared to those exhibited by the bulk counterparts. In view of the fact that dimensionality plays a key role in determining the qualities of matter, the realization of the great potential of nanotechnology has opened the door to other disciplines such as life sciences and medicine, where the merging between them offers exciting new applications, along with basic science research. The application of nanotechnology in life sciences, nanobiotechnology, is now having a profound impact on biological circuit design, bioproduction systems, synthetic biology, medical diagnostics, disease therapy and drug delivery. This special issue is dedicated to the overview of how we are learning to control biopolymers and biological machines at the molecular- and nanoscale. In addition, it covers far-reaching progress in the design and synthesis of nanoscale materials, thus enabling the construction of integrated systems in which the component blocks are comparable in size to the chemical and biological entities under investigation.
AB - Nanotechnology, the area of science focused on the control of matter in the nanometer scale, allows ground-breaking changes of the fundamental properties of matter that are often radically different compared to those exhibited by the bulk counterparts. In view of the fact that dimensionality plays a key role in determining the qualities of matter, the realization of the great potential of nanotechnology has opened the door to other disciplines such as life sciences and medicine, where the merging between them offers exciting new applications, along with basic science research. The application of nanotechnology in life sciences, nanobiotechnology, is now having a profound impact on biological circuit design, bioproduction systems, synthetic biology, medical diagnostics, disease therapy and drug delivery. This special issue is dedicated to the overview of how we are learning to control biopolymers and biological machines at the molecular- and nanoscale. In addition, it covers far-reaching progress in the design and synthesis of nanoscale materials, thus enabling the construction of integrated systems in which the component blocks are comparable in size to the chemical and biological entities under investigation.
UR - http://www.scopus.com/inward/record.url?scp=84880958365&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.copbio.2013.06.003
DO - https://doi.org/10.1016/j.copbio.2013.06.003
M3 - كلمة العدد
SN - 0958-1669
VL - 24
SP - 551
EP - 554
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 4
ER -