@article{873052cf73754c01abf0935e3a06aa33,
title = "Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties",
abstract = "Background: Myristate is a novel potential substrate for sphingoid base synthesis. Results: Myocardial sphingoid base synthesis utilizes myristate; these sphingolipids are functionally non-redundant with canonical sphingoid bases. Conclusion: d16:0 and d16:1 sphingolipids constitute an appreciable proportion of cardiac dihydrosphingosine and dihydroceramide, with distinct biological roles. Significance: This pool of sphingolipids may play a heretofore unsuspected role in myocardial pathology or protection.",
author = "Russo, {Sarah Brice} and Rotem Tidhar and Futerman, {Anthony H.} and Cowart, {L. Ashley}",
note = "National Institutes of Health (NIH), NIDDK [F30DK092125]; NIH [P30 CA138313, P20 RR017677]; NIH COBRE in Lipidomics and Pathobiology at MUSC; Department of Veterans AffairsThis work was supported, in whole or in part, by National Institutes of Health (NIH), NIDDK, Grant F30DK092125 (to S. B. R.); NIH Grant P30 CA138313 (Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina (MUSC)); NIH Grant P20 RR017677 (Lipidomics Core in the South Carolina Lipidomics and Pathobiology Centers of Biomedical Research Excellence (COBRE), Department of Biochemistry, MUSC); and the NIH COBRE in Lipidomics and Pathobiology at MUSC (to L. A. C.). This work was also supported by a Merit Award from the Department of Veterans Affairs (to L. A. C.).",
year = "2013",
month = may,
day = "10",
doi = "10.1074/jbc.M112.428185",
language = "الإنجليزيّة",
volume = "288",
pages = "13397--13409",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "19",
}