Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties

Sarah Brice Russo; Rotem Tidhar; Anthony H. Futerman; L. Ashley Cowart

doi:10.1074/jbc.M112.428185

Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties

Sarah Brice Russo
, Rotem Tidhar
, Anthony H. Futerman
, L. Ashley Cowart

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Myristate is a novel potential substrate for sphingoid base synthesis. Results: Myocardial sphingoid base synthesis utilizes myristate; these sphingolipids are functionally non-redundant with canonical sphingoid bases. Conclusion: d16:0 and d16:1 sphingolipids constitute an appreciable proportion of cardiac dihydrosphingosine and dihydroceramide, with distinct biological roles. Significance: This pool of sphingolipids may play a heretofore unsuspected role in myocardial pathology or protection.

Original language	English GB
Pages (from-to)	13397-13409
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	19
DOIs	https://doi.org/10.1074/jbc.M112.428185
State	Published - 10 May 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.428185

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title = "Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties",

abstract = "Background: Myristate is a novel potential substrate for sphingoid base synthesis. Results: Myocardial sphingoid base synthesis utilizes myristate; these sphingolipids are functionally non-redundant with canonical sphingoid bases. Conclusion: d16:0 and d16:1 sphingolipids constitute an appreciable proportion of cardiac dihydrosphingosine and dihydroceramide, with distinct biological roles. Significance: This pool of sphingolipids may play a heretofore unsuspected role in myocardial pathology or protection.",

author = "Russo, \{Sarah Brice\} and Rotem Tidhar and Futerman, \{Anthony H.\} and Cowart, \{L. Ashley\}",

note = "National Institutes of Health (NIH), NIDDK [F30DK092125]; NIH [P30 CA138313, P20 RR017677]; NIH COBRE in Lipidomics and Pathobiology at MUSC; Department of Veterans AffairsThis work was supported, in whole or in part, by National Institutes of Health (NIH), NIDDK, Grant F30DK092125 (to S. B. R.); NIH Grant P30 CA138313 (Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina (MUSC)); NIH Grant P20 RR017677 (Lipidomics Core in the South Carolina Lipidomics and Pathobiology Centers of Biomedical Research Excellence (COBRE), Department of Biochemistry, MUSC); and the NIH COBRE in Lipidomics and Pathobiology at MUSC (to L. A. C.). This work was also supported by a Merit Award from the Department of Veterans Affairs (to L. A. C.).",

year = "2013",

month = may,

day = "10",

doi = "10.1074/jbc.M112.428185",

language = "الإنجليزيّة",

volume = "288",

pages = "13397--13409",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "19",

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TY - JOUR

T1 - Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties

AU - Russo, Sarah Brice

AU - Tidhar, Rotem

AU - Futerman, Anthony H.

AU - Cowart, L. Ashley

N1 - National Institutes of Health (NIH), NIDDK [F30DK092125]; NIH [P30 CA138313, P20 RR017677]; NIH COBRE in Lipidomics and Pathobiology at MUSC; Department of Veterans AffairsThis work was supported, in whole or in part, by National Institutes of Health (NIH), NIDDK, Grant F30DK092125 (to S. B. R.); NIH Grant P30 CA138313 (Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina (MUSC)); NIH Grant P20 RR017677 (Lipidomics Core in the South Carolina Lipidomics and Pathobiology Centers of Biomedical Research Excellence (COBRE), Department of Biochemistry, MUSC); and the NIH COBRE in Lipidomics and Pathobiology at MUSC (to L. A. C.). This work was also supported by a Merit Award from the Department of Veterans Affairs (to L. A. C.).

PY - 2013/5/10

Y1 - 2013/5/10

N2 - Background: Myristate is a novel potential substrate for sphingoid base synthesis. Results: Myocardial sphingoid base synthesis utilizes myristate; these sphingolipids are functionally non-redundant with canonical sphingoid bases. Conclusion: d16:0 and d16:1 sphingolipids constitute an appreciable proportion of cardiac dihydrosphingosine and dihydroceramide, with distinct biological roles. Significance: This pool of sphingolipids may play a heretofore unsuspected role in myocardial pathology or protection.

AB - Background: Myristate is a novel potential substrate for sphingoid base synthesis. Results: Myocardial sphingoid base synthesis utilizes myristate; these sphingolipids are functionally non-redundant with canonical sphingoid bases. Conclusion: d16:0 and d16:1 sphingolipids constitute an appreciable proportion of cardiac dihydrosphingosine and dihydroceramide, with distinct biological roles. Significance: This pool of sphingolipids may play a heretofore unsuspected role in myocardial pathology or protection.

UR - https://www.scopus.com/pages/publications/84877721470

U2 - 10.1074/jbc.M112.428185

DO - 10.1074/jbc.M112.428185

M3 - مقالة

SN - 0021-9258

VL - 288

SP - 13397

EP - 13409

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 19

ER -

Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties

Abstract

ASJC Scopus subject areas

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