Mutagenic induction of an ultra-fast water-chain proton wire

Vered Wineman-Fisher; Ron Simkovich; Dan Huppert; Kristina Trujillo; S. James Remington; Yifat Miller

doi:10.1039/c6cp05071a

Mutagenic induction of an ultra-fast water-chain proton wire

Vered Wineman-Fisher, Ron Simkovich, Dan Huppert, Kristina Trujillo, S. James Remington, Yifat Miller

Ben-Gurion University of the Negev, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Replacement of the hydroxyl group of a hydrophilic sidechain by an H atom in the proton wire of GFP induces formation of a water-chain proton wire. Surprisingly, this "non-native" water chain functions as a proton wire with response times within 10 ps of the wild type protein. This remarkable rate retention is understood as a natural consequence of the well-known Grotthuss mechanism of proton transfer in water.

Original language	English
Pages (from-to)	23089-23095
Number of pages	7
Journal	Physical Chemistry Chemical Physics
Volume	18
Issue number	33
DOIs	https://doi.org/10.1039/c6cp05071a
State	Published - 1 Jan 2016

All Science Journal Classification (ASJC) codes

General Physics and Astronomy
Physical and Theoretical Chemistry

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10.1039/c6cp05071a

Cite this

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abstract = "Replacement of the hydroxyl group of a hydrophilic sidechain by an H atom in the proton wire of GFP induces formation of a water-chain proton wire. Surprisingly, this {"}non-native{"} water chain functions as a proton wire with response times within 10 ps of the wild type protein. This remarkable rate retention is understood as a natural consequence of the well-known Grotthuss mechanism of proton transfer in water.",

author = "Vered Wineman-Fisher and Ron Simkovich and Dan Huppert and Kristina Trujillo and Remington, \{S. James\} and Yifat Miller",

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AU - Remington, S. James

AU - Miller, Yifat

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AB - Replacement of the hydroxyl group of a hydrophilic sidechain by an H atom in the proton wire of GFP induces formation of a water-chain proton wire. Surprisingly, this "non-native" water chain functions as a proton wire with response times within 10 ps of the wild type protein. This remarkable rate retention is understood as a natural consequence of the well-known Grotthuss mechanism of proton transfer in water.

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M3 - مقالة

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EP - 23095

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

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ER -

Mutagenic induction of an ultra-fast water-chain proton wire

Abstract

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