Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Timur Ermatov; Roman E. Noskov; Andrey A. Machnev; Ivan Gnusov; Vsevolod Аtkin; Ekaterina N. Lazareva; Sergei V. German; Sergey S. Kosolobov; Timofei S. Zatsepin; Olga V. Sergeeva; Julia S. Skibina; Pavel Ginzburg; Valery V. Tuchin; Pavlos G. Lagoudakis; Dmitry A. Gorin

doi:10.1038/s41377-020-00410-8

Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Timur Ermatov, Roman E. Noskov, Andrey A. Machnev, Ivan Gnusov, Vsevolod Аtkin, Ekaterina N. Lazareva, Sergei V. German, Sergey S. Kosolobov, Timofei S. Zatsepin, Olga V. Sergeeva, Julia S. Skibina, Pavel Ginzburg, Valery V. Tuchin, Pavlos G. Lagoudakis, Dmitry A. Gorin

School of Electrical Engineering

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU⁻¹ in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

Original language	English
Article number	173
Journal	Light: Science and Applications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41377-020-00410-8
State	Published - 1 Dec 2020

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

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10.1038/s41377-020-00410-8

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Ermatov, T., Noskov, R. E., Machnev, A. A., Gnusov, I., Аtkin, V., Lazareva, E. N., German, S. V., Kosolobov, S. S., Zatsepin, T. S., Sergeeva, O. V., Skibina, J. S., Ginzburg, P., Tuchin, V. V., Lagoudakis, P. G., & Gorin, D. A. (2020). Multispectral sensing of biological liquids with hollow-core microstructured optical fibres. Light: Science and Applications, 9(1), Article 173. https://doi.org/10.1038/s41377-020-00410-8

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title = "Multispectral sensing of biological liquids with hollow-core microstructured optical fibres",

abstract = "The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous measurements of a bioanalyte{\textquoteright}s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU−1 in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.",

author = "Timur Ermatov and Noskov, {Roman E.} and Machnev, {Andrey A.} and Ivan Gnusov and Vsevolod Аtkin and Lazareva, {Ekaterina N.} and German, {Sergei V.} and Kosolobov, {Sergey S.} and Zatsepin, {Timofei S.} and Sergeeva, {Olga V.} and Skibina, {Julia S.} and Pavel Ginzburg and Tuchin, {Valery V.} and Lagoudakis, {Pavlos G.} and Gorin, {Dmitry A.}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "1",

doi = "10.1038/s41377-020-00410-8",

language = "الإنجليزيّة",

volume = "9",

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Ermatov, T, Noskov, RE, Machnev, AA, Gnusov, I, Аtkin, V, Lazareva, EN, German, SV, Kosolobov, SS, Zatsepin, TS, Sergeeva, OV, Skibina, JS, Ginzburg, P, Tuchin, VV, Lagoudakis, PG & Gorin, DA 2020, 'Multispectral sensing of biological liquids with hollow-core microstructured optical fibres', Light: Science and Applications, vol. 9, no. 1, 173. https://doi.org/10.1038/s41377-020-00410-8

TY - JOUR

T1 - Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

AU - Ermatov, Timur

AU - Noskov, Roman E.

AU - Machnev, Andrey A.

AU - Gnusov, Ivan

AU - Аtkin, Vsevolod

AU - Lazareva, Ekaterina N.

AU - German, Sergei V.

AU - Kosolobov, Sergey S.

AU - Zatsepin, Timofei S.

AU - Sergeeva, Olga V.

AU - Skibina, Julia S.

AU - Ginzburg, Pavel

AU - Tuchin, Valery V.

AU - Lagoudakis, Pavlos G.

AU - Gorin, Dmitry A.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU−1 in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

AB - The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU−1 in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

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DO - 10.1038/s41377-020-00410-8

M3 - مقالة

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SN - 2095-5545

VL - 9

JO - Light: Science and Applications

JF - Light: Science and Applications

IS - 1

M1 - 173

ER -

Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Abstract

All Science Journal Classification (ASJC) codes

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