Multiplex optical detection and quantification of DNA fragments by metallo-peptide assemblies

Abhijit Saha; Meital Reches

doi:10.1038/s41598-019-45124-z

Multiplex optical detection and quantification of DNA fragments by metallo-peptide assemblies

Abhijit Saha, Meital Reches

Institute of Chemistry

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Rapid detection of infectious agents such as bacteria and viruses are important for proper health management, agriculture and homeland security. This paper presents a multiplex DNA detection system self-assembled by a metallo-peptide complex. Within five minutes, the system can simultaneously detect multiple DNA fragments, without any need for their separation. The presence of proteins in the sample does not harm the detection capabilities of the system, which can discriminate even between one base-pair mismatch and can perform at concentrations as low as 200 pM.

Original language	English
Article number	8789
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-45124-z
State	Published - 1 Dec 2019

All Science Journal Classification (ASJC) codes

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10.1038/s41598-019-45124-z

Cite this

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AB - Rapid detection of infectious agents such as bacteria and viruses are important for proper health management, agriculture and homeland security. This paper presents a multiplex DNA detection system self-assembled by a metallo-peptide complex. Within five minutes, the system can simultaneously detect multiple DNA fragments, without any need for their separation. The presence of proteins in the sample does not harm the detection capabilities of the system, which can discriminate even between one base-pair mismatch and can perform at concentrations as low as 200 pM.

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Multiplex optical detection and quantification of DNA fragments by metallo-peptide assemblies

Abstract

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